Detailed information of TA system TA212408

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-RHH
• Location: 68378..68931
• Replicon: chromosome
• Accession: NZ_CP080999
• Organism: Mycobacterium malmoense strain ATCC 29571

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: K3U93_RS00330
• Protein ID: WP_083008730.1
• Coordinates: 68626..68931 (+)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: K3U93_RS00325
• Protein ID: WP_083008727.1
• Coordinates: 68378..68629 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K3U93_RS00305 (K3U93_00305)	64199..65440	+	1242	WP_083008721.1	UPF0158 family protein	-
K3U93_RS00310 (K3U93_00310)	65612..66037	-	426	WP_071512775.1	type II toxin-antitoxin system VapC family toxin	-
K3U93_RS00315 (K3U93_00315)	66030..66281	-	252	WP_071512774.1	type II toxin-antitoxin system prevent-host-death family antitoxin	-
K3U93_RS00320 (K3U93_00320)	66997..68298	+	1302	WP_083008724.1	DUF2786 domain-containing protein	-
K3U93_RS00325 (K3U93_00325)	68378..68629	+	252	WP_083008727.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
K3U93_RS00330 (K3U93_00330)	68626..68931	+	306	WP_083008730.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
K3U93_RS00335 (K3U93_00335)	69332..70336	+	1005	WP_071512769.1	glycoside hydrolase family 6 protein	-
K3U93_RS00340 (K3U93_00340)	70379..71410	-	1032	WP_083009110.1	fused (3R)-hydroxyacyl-ACP dehydratase subunits HadA/HadB	-
K3U93_RS00345 (K3U93_00345)	71632..71979	-	348	WP_083008733.1	hypothetical protein	-
K3U93_RS00350 (K3U93_00350)	72122..72721	-	600	WP_071512767.1	TetR/AcrR family transcriptional regulator	-
K3U93_RS00355 (K3U93_00355)	72830..73273	+	444	WP_083008736.1	DUF4345 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	67051..83800	16749

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-92)

Antitoxin

• Antitoxin ParD (4-72)

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 11831.29 Da
• Isoelectric Point: 5.8965

>T212408 WP_083008730.1 NZ_CP080999:68626-68931 [Mycobacterium malmoense]
MSRHVLSPAAHADLEQIWDYTCERWDDDQAEEYVREIQRAIDRVVDNPMIGRACDEVRPGYRKHTVGSHTLYCRIARGDV
IDVVRILHQRMDVDRHLDSGM

Nucleotide

• Length: 306 bp

>T212408 NZ_CP107010:842920-843318 [Salmonella enterica subsp. enterica serovar Paratyphi B]
ATGCTGAAATTCATGCTTGATACCAATACGTGTATTTTCACCATCAAAAATAAGCCCGAACACATCAGAGAACGCTTCAA
CCTCAATACATCCCGAATGTGTATCAGCTCCATCACCTTAATGGAGCTGATTTACGGTGCTGAAAAAAGCCTGGCGCCGG
AGCGTAATCTTGCCGTCGTGGAGGGATTTATCTCCCGCCTTGAGGTTCTGGATTACGATACACAGGCAGCGATACATACC
GGTCAAATCCGTGCCGAACTGGCCCGCAAGGGAACACCTGTCGGGCCTTATGACCAGATGATTGCTGGCCATGCCCGTAG
CCGCGGACTGGTCGTCGTCACAAACAATCTCCGCGAATTTGAACGCATTCCGGGTATCCGAATAGAAGACTGGTGCTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9524.44 Da
• Isoelectric Point: 8.7905

>AT212408 WP_083008727.1 NZ_CP080999:68378-68629 [Mycobacterium malmoense]
VGRNTSFSLDDHHRAFIEQEVASGRYRSASDVVRSALRLLEDRETRLSALRQALVTGEQSGESRPFDFDEFVARKRGENS
RRQ

Nucleotide

• Length: 252 bp

>AT212408 NZ_CP107010:842693-842920 [Salmonella enterica subsp. enterica serovar Paratyphi B]
ATGCACACAACACTTTTTTTTAGTAACCGGACCCAGGCAGTCAGATTGCCTAAATCGATATCCTTTCCGGAGGATGTGAA
ACATGTCGAAATCATTGCGGTTGGTAGAAGCAGAATCATTACTCCAGTCGGAGAATCCTGGGACAGCTGGTTCGATGGTG
AAGGCGCCAGTACTGATTTTATGAGCACCAGAGAACAACTCGCAGTACAGGAACGGGAAGGATTCTGA