Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1477730..1478655 Replicon chromosome
Accession NZ_CP080997
Organism Mycolicibacter heraklionensis strain JCM 30995

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag K3U94_RS07025 Protein ID WP_230987480.1
Coordinates 1477730..1478227 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag K3U94_RS07030 Protein ID WP_220696033.1
Coordinates 1478224..1478655 (-) Length 144 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K3U94_RS23625 1474174..1474548 - 375 WP_230987474.1 hypothetical protein -
K3U94_RS07005 (K3U94_07005) 1474852..1475058 + 207 WP_220696029.1 hypothetical protein -
K3U94_RS07010 (K3U94_07010) 1475215..1475706 - 492 WP_230987475.1 MarR family transcriptional regulator -
K3U94_RS07015 (K3U94_07015) 1475859..1476380 - 522 WP_220696030.1 TetR family transcriptional regulator -
K3U94_RS07020 (K3U94_07020) 1476519..1477688 + 1170 WP_220696031.1 acyl-CoA dehydrogenase family protein -
K3U94_RS07025 (K3U94_07025) 1477730..1478227 - 498 WP_230987480.1 GNAT family N-acetyltransferase Toxin
K3U94_RS07030 (K3U94_07030) 1478224..1478655 - 432 WP_220696033.1 DUF1778 domain-containing protein Antitoxin
K3U94_RS07035 (K3U94_07035) 1478985..1479326 + 342 WP_220696034.1 helix-turn-helix transcriptional regulator -
K3U94_RS07040 (K3U94_07040) 1479323..1479790 - 468 WP_220696035.1 hypothetical protein -
K3U94_RS23630 1479904..1480005 - 102 Protein_1396 hypothetical protein -
K3U94_RS07045 (K3U94_07045) 1480190..1481374 + 1185 WP_220696036.1 Fic family protein -
K3U94_RS07050 (K3U94_07050) 1481424..1481720 - 297 WP_220696037.1 helix-turn-helix transcriptional regulator -
K3U94_RS07055 (K3U94_07055) 1481725..1482066 - 342 WP_220696038.1 type II toxin-antitoxin system RelE/ParE family toxin -
K3U94_RS07060 (K3U94_07060) 1482079..1482384 + 306 WP_220696039.1 hypothetical protein -
K3U94_RS07065 (K3U94_07065) 1482527..1482775 + 249 WP_220696040.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
K3U94_RS07070 (K3U94_07070) 1482792..1483172 + 381 WP_230987482.1 type II toxin-antitoxin system VapC family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-143)

Antitoxin

Vibrio phage ICP1, Orf50

(51-139)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18030.50 Da        Isoelectric Point: 8.5146

>T212400 WP_230987480.1 NZ_CP080997:c1478227-1477730 [Mycolicibacter heraklionensis]
VSYSFPRPIAQADEVAAFDSGEPSLDDYLRRKALANHIEGGSRCFVTTIGRRVVGYYCLAAGSVQHQDAPGRVRRNMPRP
VPVILLSRLAVDREERGNGLGSHLLRDAITRSAQAADTIGVRAILVHALHSDAASFYRHFDFMPSPTDDLHLTLLIKDAR
ALLGG

Download         Length: 498 bp

>T212400 NZ_CP107007:374704-374886 [Halomonas sp. GD1P12]
GTGAAAAGCAGGGAACTTATCAAAGAGATGGAGGCCGACGGCTGGTATCTCGATCGTGTTAGTGGGAGCCATCACGTATT
CAAGCATTCCACCAAACCCGGCAGCGTGCCCGTCCCTCATCCAAAAAAGGATTTACCCAAGGGGACTATCCACAGCATCA
GGAAACTCGCTGGGCTCAAGTAG

Antitoxin


Download         Length: 144 a.a.        Molecular weight: 15702.67 Da        Isoelectric Point: 9.2141

>AT212400 WP_220696033.1 NZ_CP080997:c1478655-1478224 [Mycolicibacter heraklionensis]
MAEQRGKTDPDRGRPAGKPVASSAQTGRHIAPRDCSNKTIRVSADGKWTSGERKTSRLTARLTPDQDAIIRHAAELTGTD
ITNFTITTLLARAADILADRRLFILDDAAWTEFNAMLDAPASPKPRLEKLFSEPSVFDTTPER

Download         Length: 432 bp

>AT212400 NZ_CP107007:374910-375314 [Halomonas sp. GD1P12]
ATGCAATATCCGATTGCCATCGAATGGGGCGACGAGAATACCGCTACCGGTATCGTGATTCCCGATATTCCCGGCGCCGT
GACAGCGGGCGACACGACCGAACACGCCTATGAGATGGCGGTGGAGGTGGCCCATATCCAGTTGGAAGAACTGGCCAACG
ATAACAAGGATATTCCCATGCCTCGCAGCATCGCGGAGCATCGTAGGAATCCACAATTCGAAGGATACGGTTGGGGGATT
ATCGATATCGATATCACTCCCTATCTCGGCAAAACTGAAAAGGTGAACGTTACCTTGCCTGGCCACGTCATCCGCCAGAT
CGATAAATACGTGACCACCCACGGCATCAAAAGCCGCTCTGCGTTCATTGCCTCGGCGGCGTTGGAAAAGCTGACCCACG
CGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References