Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-PHD
Location 1433939..1434564 Replicon chromosome
Accession NZ_CP080997
Organism Mycolicibacter heraklionensis strain JCM 30995

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag K3U94_RS06845 Protein ID WP_220696007.1
Coordinates 1433939..1434319 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag K3U94_RS06850 Protein ID WP_220696008.1
Coordinates 1434316..1434564 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K3U94_RS06810 (K3U94_06810) 1429397..1430284 + 888 WP_047320158.1 transcriptional regulator CynR -
K3U94_RS06815 (K3U94_06815) 1430383..1430886 + 504 WP_047320116.1 nucleoside deaminase -
K3U94_RS06820 (K3U94_06820) 1430941..1431378 + 438 WP_047320157.1 MarR family transcriptional regulator -
K3U94_RS06825 (K3U94_06825) 1431445..1432263 + 819 WP_047320115.1 uracil-DNA glycosylase -
K3U94_RS06830 (K3U94_06830) 1432279..1432515 - 237 WP_047320114.1 hypothetical protein -
K3U94_RS06835 (K3U94_06835) 1432569..1432769 - 201 WP_230987460.1 BrnT family toxin -
K3U94_RS06840 (K3U94_06840) 1432866..1433897 + 1032 WP_220696703.1 LLM class flavin-dependent oxidoreductase -
K3U94_RS06845 (K3U94_06845) 1433939..1434319 - 381 WP_220696007.1 type II toxin-antitoxin system VapC family toxin Toxin
K3U94_RS06850 (K3U94_06850) 1434316..1434564 - 249 WP_220696008.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
K3U94_RS24295 (K3U94_06855) 1434600..1438649 - 4050 WP_220696009.1 PecA family PE domain-processing aspartic protease -
K3U94_RS06860 (K3U94_06860) 1438721..1439176 - 456 WP_220696010.1 nitroreductase family deazaflavin-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(20-110)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-67)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13212.36 Da        Isoelectric Point: 8.6788

>T212399 WP_220696007.1 NZ_CP080997:c1434319-1433939 [Mycolicibacter heraklionensis]
MIAILDTSVVIATGVAPLQGELAVSTITLAELHFGVLVAKLPEVRAERLRRLSVLQRSFDALPLTGSVAASYGQIAAAVT
AAGRQPRARSMDLLIAATAHAHSARLYTRNPADFAGLDNLLEVVAV

Download         Length: 381 bp

>T212399 NZ_CP107005:c4215162-4214989 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9321.33 Da        Isoelectric Point: 4.5098

>AT212399 WP_220696008.1 NZ_CP080997:c1434564-1434316 [Mycolicibacter heraklionensis]
METVGLRELRQNASDLVRRVEDGEEITITVAGRPSARLVPAAPRAWRRWTDIAELFNGPEDPAWSDDRETIEHAIADPWN
AR

Download         Length: 249 bp

>AT212399 NZ_CP107005:c4215486-4215190 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References