Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/RelE-Phd |
| Location | 1265162..1265706 | Replicon | chromosome |
| Accession | NZ_CP080997 | ||
| Organism | Mycolicibacter heraklionensis strain JCM 30995 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | - |
| Locus tag | K3U94_RS06035 | Protein ID | WP_220695902.1 |
| Coordinates | 1265443..1265706 (+) | Length | 88 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | A0A0I9TNW4 |
| Locus tag | K3U94_RS06030 | Protein ID | WP_047317649.1 |
| Coordinates | 1265162..1265446 (+) | Length | 95 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K3U94_RS06010 (K3U94_06010) | 1260597..1261289 | - | 693 | WP_220695898.1 | DUF4433 domain-containing protein | - |
| K3U94_RS06015 (K3U94_06015) | 1261819..1262667 | - | 849 | WP_230987446.1 | ImmA/IrrE family metallo-endopeptidase | - |
| K3U94_RS06020 (K3U94_06020) | 1263074..1263679 | - | 606 | WP_220695900.1 | hypothetical protein | - |
| K3U94_RS06025 (K3U94_06025) | 1263904..1264911 | + | 1008 | WP_220695901.1 | alpha/beta hydrolase | - |
| K3U94_RS06030 (K3U94_06030) | 1265162..1265446 | + | 285 | WP_047317649.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| K3U94_RS06035 (K3U94_06035) | 1265443..1265706 | + | 264 | WP_220695902.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| K3U94_RS06040 (K3U94_06040) | 1265773..1266054 | + | 282 | WP_220695903.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| K3U94_RS06045 (K3U94_06045) | 1266029..1266349 | + | 321 | WP_220695904.1 | HigA family addiction module antitoxin | - |
| K3U94_RS06050 (K3U94_06050) | 1266554..1266865 | + | 312 | WP_220695905.1 | hypothetical protein | - |
| K3U94_RS06055 (K3U94_06055) | 1266802..1267212 | - | 411 | WP_220695906.1 | NAD(+)--rifampin ADP-ribosyltransferase | - |
| K3U94_RS06060 (K3U94_06060) | 1267311..1267625 | + | 315 | WP_220695907.1 | hypothetical protein | - |
| K3U94_RS06065 (K3U94_06065) | 1267942..1269024 | - | 1083 | WP_220695908.1 | IS110 family transposase | - |
| K3U94_RS06070 (K3U94_06070) | 1269195..1269548 | - | 354 | WP_046283854.1 | hypothetical protein | - |
| K3U94_RS06075 (K3U94_06075) | 1269650..1270162 | + | 513 | WP_047317223.1 | OsmC family protein | - |
| K3U94_RS06080 (K3U94_06080) | 1270168..1270491 | + | 324 | WP_220695909.1 | putative quinol monooxygenase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 88 a.a. Molecular weight: 10386.93 Da Isoelectric Point: 9.7879
>T212397 WP_220695902.1 NZ_CP080997:1265443-1265706 [Mycolicibacter heraklionensis]
MTYRVELTRRARRSLCEELPGVVAAACWEFIRGPLAENPQRVGKHLRDELADRWSARRGEFRVVYEIHEDVVVVRVIDVR
HRRDVYR
MTYRVELTRRARRSLCEELPGVVAAACWEFIRGPLAENPQRVGKHLRDELADRWSARRGEFRVVYEIHEDVVVVRVIDVR
HRRDVYR
Download Length: 264 bp
>T212397 NZ_CP107005:4032571-4032828 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA
Antitoxin
Download Length: 95 a.a. Molecular weight: 10347.71 Da Isoelectric Point: 4.4558
>AT212397 WP_047317649.1 NZ_CP080997:1265162-1265446 [Mycolicibacter heraklionensis]
MTTLPLAEVRANLSKLVDEAVRTHQRVEVTKNGRRAAVLISADDYDSLIETLEILGDREAMEAIREADADIAAGRVYPLN
EVEAELRARGIITS
MTTLPLAEVRANLSKLVDEAVRTHQRVEVTKNGRRAAVLISADDYDSLIETLEILGDREAMEAIREADADIAAGRVYPLN
EVEAELRARGIITS
Download Length: 285 bp
>AT212397 NZ_CP107005:4032840-4033385 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|