Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4611791..4612307 Replicon chromosome
Accession NZ_CP080960
Organism Salmonella enterica subsp. enterica serovar Typhi strain ISP2825

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag K3U68_RS22655 Protein ID WP_000220578.1
Coordinates 4612023..4612307 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag K3U68_RS22650 Protein ID WP_000212724.1
Coordinates 4611791..4612033 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K3U68_RS22630 (K3U68_22630) 4606811..4607944 + 1134 WP_000459938.1 amidohydrolase/deacetylase family metallohydrolase -
K3U68_RS22635 (K3U68_22635) 4607928..4609046 + 1119 WP_001139189.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
K3U68_RS22640 (K3U68_22640) 4609043..4609783 + 741 WP_000779260.1 KDGP aldolase family protein -
K3U68_RS22645 (K3U68_22645) 4609800..4611713 + 1914 WP_001212152.1 BglG family transcription antiterminator -
K3U68_RS22650 (K3U68_22650) 4611791..4612033 + 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
K3U68_RS22655 (K3U68_22655) 4612023..4612307 + 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K3U68_RS22660 (K3U68_22660) 4612311..4612775 - 465 WP_001268860.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
K3U68_RS22665 (K3U68_22665) 4612896..4615034 - 2139 WP_000187820.1 anaerobic ribonucleoside-triphosphate reductase -
K3U68_RS22670 (K3U68_22670) 4615443..4617095 - 1653 WP_000155051.1 alpha,alpha-phosphotrehalase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T212391 WP_000220578.1 NZ_CP080960:4612023-4612307 [Salmonella enterica subsp. enterica serovar Typhi]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T212391 NZ_CP107005:2670509-2670616 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT212391 WP_000212724.1 NZ_CP080960:4611791-4612033 [Salmonella enterica subsp. enterica serovar Typhi]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT212391 NZ_CP107005:c2670462-2670396 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References