Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4494475..4495253 Replicon chromosome
Accession NZ_CP080960
Organism Salmonella enterica subsp. enterica serovar Typhi strain ISP2825

Toxin (Protein)


Gene name TacT2 Uniprot ID Q8Z1C2
Locus tag K3U68_RS22040 Protein ID WP_000622308.1
Coordinates 4494765..4495253 (+) Length 163 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID Q8Z1C3
Locus tag K3U68_RS22035 Protein ID WP_001143724.1
Coordinates 4494475..4494768 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K3U68_RS22020 (K3U68_22020) 4489787..4491298 + 1512 WP_001120833.1 UvrD-helicase domain-containing protein -
K3U68_RS22025 (K3U68_22025) 4491282..4492871 + 1590 WP_000488995.1 TraI domain-containing protein -
K3U68_RS22030 (K3U68_22030) 4493035..4494048 + 1014 WP_000449622.1 site-specific integrase -
K3U68_RS22035 (K3U68_22035) 4494475..4494768 + 294 WP_001143724.1 DUF1778 domain-containing protein Antitoxin
K3U68_RS22040 (K3U68_22040) 4494765..4495253 + 489 WP_000622308.1 GNAT family N-acetyltransferase Toxin
K3U68_RS22045 (K3U68_22045) 4495433..4495885 - 453 WP_000434168.1 hypothetical protein -
K3U68_RS22050 (K3U68_22050) 4495967..4496218 - 252 WP_024131240.1 hypothetical protein -
K3U68_RS22055 (K3U68_22055) 4496522..4498807 - 2286 WP_010989300.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - sopE2 / vexE / vexD / vexC / vexB / vexA / tviE / tviD / tviC / tviB 4232517..4497789 265272


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 163 a.a.        Molecular weight: 17538.36 Da        Isoelectric Point: 7.3252

>T212390 WP_000622308.1 NZ_CP080960:4494765-4495253 [Salmonella enterica subsp. enterica serovar Typhi]
MISAPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQVTGASRTFVCCGSDSDVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPVVVLGRLAVDRSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYLRVGFEPSPMDPMMLMVTLGDLV
HA

Download         Length: 489 bp

>T212390 NZ_CP107005:c2382413-2382237 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10906.59 Da        Isoelectric Point: 6.3493

>AT212390 WP_001143724.1 NZ_CP080960:4494475-4494768 [Salmonella enterica subsp. enterica serovar Typhi]
MPVANSMAMKRETLNLRIKPAERDLIDRAAKARGKNCTDFVLEAARAAAEEALIEQRIIMADPEAYQAFLIRLDQAPAPN
DALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT212390 NZ_CP107005:c2382191-2381775 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A716G941

Antitoxin

Source ID Structure
AlphaFold DB A0A716D9M3

References