Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3841240..3842000 Replicon chromosome
Accession NZ_CP080960
Organism Salmonella enterica subsp. enterica serovar Typhi strain ISP2825

Toxin (Protein)


Gene name tacT Uniprot ID Q8Z2B1
Locus tag K3U68_RS18825 Protein ID WP_000533908.1
Coordinates 3841515..3842000 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID Q8Z2B2
Locus tag K3U68_RS18820 Protein ID WP_000965889.1
Coordinates 3841240..3841527 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K3U68_RS18800 (K3U68_18800) 3836645..3837556 + 912 WP_001168555.1 glycine--tRNA ligase subunit alpha -
K3U68_RS18805 (K3U68_18805) 3837566..3839635 + 2070 WP_001291805.1 glycine--tRNA ligase subunit beta -
K3U68_RS23630 3840025..3840453 + 429 Protein_3681 IS3 family transposase -
K3U68_RS18815 (K3U68_18815) 3840595..3841062 + 468 WP_000702452.1 GNAT family N-acetyltransferase -
K3U68_RS18820 (K3U68_18820) 3841240..3841527 + 288 WP_000965889.1 DUF1778 domain-containing protein Antitoxin
K3U68_RS18825 (K3U68_18825) 3841515..3842000 + 486 WP_000533908.1 GNAT family N-acetyltransferase Toxin
K3U68_RS18830 (K3U68_18830) 3842371..3842910 - 540 WP_000047148.1 copper-binding periplasmic metallochaperone CueP -
K3U68_RS18835 (K3U68_18835) 3843086..3843298 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
K3U68_RS18840 (K3U68_18840) 3843589..3843876 - 288 Protein_3687 HTH-type transcriptional regulator -
K3U68_RS18845 (K3U68_18845) 3844315..3845025 + 711 WP_000190524.1 DUF3053 domain-containing protein -
K3U68_RS18850 (K3U68_18850) 3845075..3846049 - 975 WP_000804690.1 glyoxylate/hydroxypyruvate reductase GhrB -
K3U68_RS18855 (K3U68_18855) 3846268..3846930 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(13-89)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17689.38 Da        Isoelectric Point: 9.8719

>T212388 WP_000533908.1 NZ_CP080960:3841515-3842000 [Salmonella enterica subsp. enterica serovar Typhi]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEDAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T212388 NZ_CP107005:2247036-2247323 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10964.59 Da        Isoelectric Point: 4.6811

>AT212388 WP_000965889.1 NZ_CP080960:3841240-3841527 [Salmonella enterica subsp. enterica serovar Typhi]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACRAAENVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT212388 NZ_CP107005:2246797-2247036 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A714MHS9

Antitoxin

Source ID Structure
AlphaFold DB A0A752RW74

References