Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/LOTUS_5_Limkain_b1(toxin) |
| Location | 3534955..3535571 | Replicon | chromosome |
| Accession | NZ_CP080960 | ||
| Organism | Salmonella enterica subsp. enterica serovar Typhi strain ISP2825 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | Q8Z2U3 |
| Locus tag | K3U68_RS17380 | Protein ID | WP_000238494.1 |
| Coordinates | 3534955..3535329 (-) | Length | 125 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | A0A8E9YHE9 |
| Locus tag | K3U68_RS17385 | Protein ID | WP_001523745.1 |
| Coordinates | 3535329..3535571 (-) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K3U68_RS17365 (K3U68_17365) | 3532457..3533359 | + | 903 | WP_000331359.1 | formate dehydrogenase subunit beta | - |
| K3U68_RS17370 (K3U68_17370) | 3533356..3533991 | + | 636 | WP_000829025.1 | formate dehydrogenase cytochrome b556 subunit | - |
| K3U68_RS17375 (K3U68_17375) | 3533988..3534917 | + | 930 | WP_000027727.1 | formate dehydrogenase accessory protein FdhE | - |
| K3U68_RS17380 (K3U68_17380) | 3534955..3535329 | - | 375 | WP_000238494.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| K3U68_RS17385 (K3U68_17385) | 3535329..3535571 | - | 243 | WP_001523745.1 | CopG family transcriptional regulator | Antitoxin |
| K3U68_RS17390 (K3U68_17390) | 3535776..3536705 | + | 930 | WP_001162859.1 | alpha/beta hydrolase | - |
| K3U68_RS17395 (K3U68_17395) | 3536791..3537102 | + | 312 | WP_000558160.1 | type II toxin-antitoxin system HigB family toxin | - |
| K3U68_RS17400 (K3U68_17400) | 3537099..3537545 | + | 447 | WP_001259009.1 | type II toxin-antitoxin system HigA family antitoxin | - |
| K3U68_RS17405 (K3U68_17405) | 3537560..3538501 | - | 942 | WP_001518251.1 | fatty acid biosynthesis protein FabY | - |
| K3U68_RS17410 (K3U68_17410) | 3538546..3538983 | - | 438 | WP_000560975.1 | D-aminoacyl-tRNA deacylase | - |
| K3U68_RS17415 (K3U68_17415) | 3538980..3539852 | - | 873 | WP_000921423.1 | virulence factor BrkB family protein | - |
| K3U68_RS17420 (K3U68_17420) | 3539846..3540445 | - | 600 | WP_000965695.1 | glucose-1-phosphatase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 125 a.a. Molecular weight: 13908.18 Da Isoelectric Point: 7.3567
>T212386 WP_000238494.1 NZ_CP080960:c3535329-3534955 [Salmonella enterica subsp. enterica serovar Typhi]
MVKGSALFDTNILIDLFSGRIEAKHALEAYPPQNAISLITWMEVMVGAKKYHQENRTRIALSAFNIIGVTQEIAERSVIV
RQEYGMKLPDAIILATAQVHRCELVTRNTKDFADIPGVITPYHL
MVKGSALFDTNILIDLFSGRIEAKHALEAYPPQNAISLITWMEVMVGAKKYHQENRTRIALSAFNIIGVTQEIAERSVIV
RQEYGMKLPDAIILATAQVHRCELVTRNTKDFADIPGVITPYHL
Download Length: 375 bp
>T212386 NZ_CP107005:c1812379-1812005 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA
Antitoxin
Download Length: 81 a.a. Molecular weight: 9437.77 Da Isoelectric Point: 4.4463
>AT212386 WP_001523745.1 NZ_CP080960:c3535571-3535329 [Salmonella enterica subsp. enterica serovar Typhi]
MMAGMDMGRILLDLSDDVIKRLDDLKVQRNLPRAELLREAVEQYLERQDRAETTISKALGLWQGCEEDGVEYQRKLREEW
MMAGMDMGRILLDLSDDVIKRLDDLKVQRNLPRAELLREAVEQYLERQDRAETTISKALGLWQGCEEDGVEYQRKLREEW
Download Length: 243 bp
>AT212386 NZ_CP107005:c1812836-1812468 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGATTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGATTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|