Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3034833..3035481 Replicon chromosome
Accession NZ_CP080960
Organism Salmonella enterica subsp. enterica serovar Typhi strain ISP2825

Toxin (Protein)


Gene name cptA Uniprot ID A0A715BCB4
Locus tag K3U68_RS14930 Protein ID WP_000244762.1
Coordinates 3034833..3035234 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag K3U68_RS14935 Protein ID WP_000351186.1
Coordinates 3035215..3035481 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K3U68_RS14910 (K3U68_14910) 3030762..3032495 - 1734 WP_000813396.1 single-stranded-DNA-specific exonuclease RecJ -
K3U68_RS14915 (K3U68_14915) 3032501..3033214 - 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
K3U68_RS14920 (K3U68_14920) 3033238..3034134 - 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
K3U68_RS14925 (K3U68_14925) 3034247..3034768 + 522 WP_001055885.1 flavodoxin FldB -
K3U68_RS14930 (K3U68_14930) 3034833..3035234 - 402 WP_000244762.1 protein YgfX Toxin
K3U68_RS14935 (K3U68_14935) 3035215..3035481 - 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
K3U68_RS14940 (K3U68_14940) 3035731..3036711 + 981 WP_000874170.1 tRNA-modifying protein YgfZ -
K3U68_RS14945 (K3U68_14945) 3036827..3037486 - 660 WP_000250289.1 hemolysin III family protein -
K3U68_RS14950 (K3U68_14950) 3037650..3037961 - 312 WP_001182971.1 N(4)-acetylcytidine aminohydrolase -
K3U68_RS14955 (K3U68_14955) 3038120..3039553 + 1434 WP_001230148.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15773.75 Da        Isoelectric Point: 10.7537

>T212385 WP_000244762.1 NZ_CP080960:c3035234-3034833 [Salmonella enterica subsp. enterica serovar Typhi]
VVLWQSDLRVSWRAQWISLLLHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPI

Download         Length: 402 bp

>T212385 NZ_CP107005:1800483-1800737 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT212385 WP_000351186.1 NZ_CP080960:c3035481-3035215 [Salmonella enterica subsp. enterica serovar Typhi]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT212385 NZ_CP107005:1800235-1800486 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A715BCB4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References