Detailed information of TA system TA212384

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 3004067..3004692
• Replicon: chromosome
• Accession: NZ_CP080960
• Organism: Salmonella enterica subsp. enterica serovar Typhi strain ISP2825

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: K3U68_RS14740
• Protein ID: WP_000911334.1
• Coordinates: 3004067..3004465 (-)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: M7S3S8
• Locus tag: K3U68_RS14745
• Protein ID: WP_000557549.1
• Coordinates: 3004465..3004692 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K3U68_RS14725 (K3U68_14725)	3000745..3001326	-	582	WP_001244646.1	fimbrial protein	-
K3U68_RS14730 (K3U68_14730)	3002045..3002677	-	633	WP_000835268.1	YfdX family protein	-
K3U68_RS14735 (K3U68_14735)	3002724..3003260	-	537	WP_001038500.1	STM3031 family outer membrane protein	-
K3U68_RS14740 (K3U68_14740)	3004067..3004465	-	399	WP_000911334.1	tRNA(fMet)-specific endonuclease VapC	Toxin
K3U68_RS14745 (K3U68_14745)	3004465..3004692	-	228	WP_000557549.1	toxin-antitoxin system antitoxin VapB	Antitoxin
K3U68_RS14750 (K3U68_14750)	3004869..3005120	+	252	WP_001540858.1	hypothetical protein	-
K3U68_RS14755 (K3U68_14755)	3005395..3006201	+	807	WP_077905073.1	DUF1460 domain-containing protein	-
K3U68_RS14760 (K3U68_14760)	3006834..3007955	-	1122	WP_000028980.1	hypothetical protein	-
K3U68_RS14765 (K3U68_14765)	3008057..3008512	-	456	WP_223229661.1	hypothetical protein	-
K3U68_RS14770 (K3U68_14770)	3008595..3008798	-	204	WP_000184036.1	hypothetical protein	-
K3U68_RS14775 (K3U68_14775)	3008802..3009521	-	720	WP_000082599.1	Rha family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2994877..3024727	29850

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-123)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 15091.44 Da
• Isoelectric Point: 7.7785

>T212384 WP_000911334.1 NZ_CP080960:c3004465-3004067 [Salmonella enterica subsp. enterica serovar Typhi]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNFAVVEGFISRLEVLDYDTQAAIHT
GQIRTELARKGTPVGSYDQMIAGHARSRGLVVVTNNLREFERIPGIRIEDWC

Nucleotide

• Length: 399 bp

>T212384 NZ_CP107005:1800235-1800486 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8514.51 Da
• Isoelectric Point: 5.0210

>AT212384 WP_000557549.1 NZ_CP080960:c3004692-3004465 [Salmonella enterica subsp. enterica serovar Typhi]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Nucleotide

• Length: 228 bp

>AT212384 NZ_CP107005:1800483-1800737 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Structures

Antitoxin

• PDB: 6IFM
• AlphaFold DB: A0A3V2Y5V5