Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2435972..2436592 Replicon chromosome
Accession NZ_CP080960
Organism Salmonella enterica subsp. enterica serovar Typhi strain ISP2825

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag K3U68_RS12025 Protein ID WP_001280991.1
Coordinates 2436374..2436592 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag K3U68_RS12020 Protein ID WP_000344807.1
Coordinates 2435972..2436346 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K3U68_RS12010 (K3U68_12010) 2431111..2432304 + 1194 WP_001039199.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
K3U68_RS12015 (K3U68_12015) 2432327..2435476 + 3150 WP_001132507.1 efflux RND transporter permease AcrB -
K3U68_RS12020 (K3U68_12020) 2435972..2436346 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
K3U68_RS12025 (K3U68_12025) 2436374..2436592 + 219 WP_001280991.1 HHA domain-containing protein Toxin
K3U68_RS12030 (K3U68_12030) 2436771..2437322 + 552 WP_001278793.1 maltose O-acetyltransferase -
K3U68_RS12035 (K3U68_12035) 2437440..2437910 + 471 WP_000136183.1 YlaC family protein -
K3U68_RS12040 (K3U68_12040) 2437966..2438106 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
K3U68_RS12045 (K3U68_12045) 2438112..2438372 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
K3U68_RS12050 (K3U68_12050) 2438597..2440147 + 1551 WP_000213129.1 EAL domain-containing protein -
K3U68_RS12060 (K3U68_12060) 2440378..2440767 + 390 WP_000961285.1 MGMT family protein -
K3U68_RS12065 (K3U68_12065) 2440800..2441369 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T212382 WP_001280991.1 NZ_CP080960:2436374-2436592 [Salmonella enterica subsp. enterica serovar Typhi]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T212382 NZ_CP107005:c1111740-1111411 [Escherichia coli]
ATGAACACTCTACCTGCTACAATTTCGCAGGCGGCGAAGCCCTGCCTGTCGCCAGTGGCTGTCTGGCAAATGCTACTGAC
ACGCCTGCTGGAACAACACTATGGCCTGACACTGAACGACACGCCGTTCAGTGATGAAACTGTTATTAAGGAACATATCG
ATGCTGGTATCACTCTGGCCGATGCAGTCAATTTTCTGGTGGAAAAGTACGAACTGGTACGTATCGATCACAGAGGATTT
TCGTGGCAACAACAGTCTCCATATATTTCCGTAGTAGATATTCTGCGAGCAAGGCGCTCTACCGGCTTGCTAAAAACTAA
TGTGAAATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT212382 WP_000344807.1 NZ_CP080960:2435972-2436346 [Salmonella enterica subsp. enterica serovar Typhi]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT212382 NZ_CP107005:c1112078-1111761 [Escherichia coli]
ATGAGCAACACCACATGGGGCCTGCAGCGAGATATCACGCCGCGCCTGGGAGCACGTCTGGTGCAGGAGGGCAACCAGCT
GCACTATCTGGCTGACCGGGCCAGTATCACCGGTAAGTTTAGTGACGCCGAATGTCCTAAGCTGGATGTGGTATTTCCAC
ATTTTATCAGCCAGATAGAGTCGATGCTGACCACTGGTGAACTGAATCCCCGCCATGCCCAATGCGTCACCCTGTACCAC
AACGGTTTTACCTGCGAAGCCGATACTCTTGGTAGTTGCGGCTACGTATACATCGCTGTTTACCCCACTCAACGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References