Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_19(antitoxin)
Location 2016137..2016925 Replicon chromosome
Accession NZ_CP080770
Organism Staphylococcus aureus strain HL23187

Toxin (Protein)


Gene name - Uniprot ID A0A2I7Y5B3
Locus tag HLV54_RS09990 Protein ID WP_000525004.1
Coordinates 2016464..2016925 (+) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0E7YIA0
Locus tag HLV54_RS09985 Protein ID WP_000333630.1
Coordinates 2016137..2016451 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HLV54_RS09930 (HLV54_001986) 2011544..2012167 - 624 WP_000139720.1 DUF1071 domain-containing protein -
HLV54_RS09935 (HLV54_001987) 2012160..2012381 - 222 WP_001077280.1 DUF2483 family protein -
HLV54_RS09940 (HLV54_001988) 2012391..2012651 - 261 WP_000291090.1 DUF1108 family protein -
HLV54_RS09945 (HLV54_001989) 2012748..2012909 - 162 WP_103215249.1 DUF1270 family protein -
HLV54_RS09950 (HLV54_001990) 2012902..2013123 - 222 WP_000594789.1 hypothetical protein -
HLV54_RS09955 (HLV54_001991) 2013194..2013424 + 231 WP_000395455.1 hypothetical protein -
HLV54_RS09960 (HLV54_001992) 2013600..2014340 - 741 WP_001148589.1 phage antirepressor KilAC domain-containing protein -
HLV54_RS09965 (HLV54_001993) 2014342..2014527 - 186 WP_000933365.1 helix-turn-helix transcriptional regulator -
HLV54_RS09970 (HLV54_001994) 2014973..2015455 + 483 WP_000394410.1 hypothetical protein -
HLV54_RS09975 (HLV54_001995) 2015556..2015735 - 180 WP_000438352.1 hypothetical protein -
HLV54_RS09980 (HLV54_001996) 2015749..2015985 - 237 WP_001121116.1 helix-turn-helix transcriptional regulator -
HLV54_RS09985 (HLV54_001997) 2016137..2016451 + 315 WP_000333630.1 helix-turn-helix transcriptional regulator Antitoxin
HLV54_RS09990 (HLV54_001998) 2016464..2016925 + 462 WP_000525004.1 hypothetical protein Toxin
HLV54_RS14260 2016943..2017077 + 135 WP_001233917.1 hypothetical protein -
HLV54_RS09995 (HLV54_001999) 2017109..2018041 + 933 WP_170171885.1 hypothetical protein -
HLV54_RS10000 (HLV54_002000) 2018021..2018200 - 180 WP_000337827.1 hypothetical protein -
HLV54_RS10005 (HLV54_002001) 2018313..2019359 + 1047 WP_001145722.1 tyrosine-type recombinase/integrase -
HLV54_RS10010 (HLV54_002002) 2019404..2020549 + 1146 WP_061820372.1 radical SAM/CxCxxxxC motif protein YfkAB -
HLV54_RS10015 (HLV54_002003) 2020809..2021339 - 531 WP_000184381.1 acyl-CoA thioesterase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1975585..2019359 43774


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(4-62)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 18074.46 Da        Isoelectric Point: 4.6915

>T212353 WP_000525004.1 NZ_CP080770:2016464-2016925 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI

Download         Length: 462 bp

>T212353 NZ_CP107004:c605876-605412 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12063.56 Da        Isoelectric Point: 6.4736

>AT212353 WP_000333630.1 NZ_CP080770:2016137-2016451 [Staphylococcus aureus]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK

Download         Length: 315 bp

>AT212353 NZ_CP107004:c606211-605876 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y5B3

Antitoxin

Source ID Structure
AlphaFold DB A0A0E7YIA0

References