Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TscAT/- |
| Location | 876039..876571 | Replicon | chromosome |
| Accession | NZ_CP080770 | ||
| Organism | Staphylococcus aureus strain HL23187 | ||
Toxin (Protein)
| Gene name | TscT | Uniprot ID | Q93CD4 |
| Locus tag | HLV54_RS04145 | Protein ID | WP_001103942.1 |
| Coordinates | 876251..876571 (+) | Length | 107 a.a. |
Antitoxin (Protein)
| Gene name | TscA | Uniprot ID | - |
| Locus tag | HLV54_RS04140 | Protein ID | WP_001058486.1 |
| Coordinates | 876039..876248 (+) | Length | 70 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HLV54_RS04095 (HLV54_000819) | 871059..872279 | - | 1221 | WP_000266157.1 | site-specific integrase | - |
| HLV54_RS04100 (HLV54_000820) | 872367..873095 | - | 729 | WP_000733774.1 | staphylococcal enterotoxin type K | - |
| HLV54_RS04105 (HLV54_000821) | 873119..873847 | - | 729 | WP_001033318.1 | staphylococcal enterotoxin type Q | - |
| HLV54_RS04110 (HLV54_000822) | 873917..874348 | - | 432 | WP_001228759.1 | hypothetical protein | - |
| HLV54_RS04115 (HLV54_000823) | 874365..874823 | - | 459 | WP_000281657.1 | ImmA/IrrE family metallo-endopeptidase | - |
| HLV54_RS04120 (HLV54_000824) | 874835..875167 | - | 333 | WP_001260004.1 | helix-turn-helix transcriptional regulator | - |
| HLV54_RS04125 (HLV54_000825) | 875360..875623 | + | 264 | WP_000243851.1 | helix-turn-helix transcriptional regulator | - |
| HLV54_RS04130 (HLV54_000826) | 875616..875888 | + | 273 | WP_000091731.1 | helix-turn-helix domain-containing protein | - |
| HLV54_RS04135 (HLV54_000827) | 875900..876046 | + | 147 | WP_000784875.1 | hypothetical protein | - |
| HLV54_RS04140 (HLV54_000828) | 876039..876248 | + | 210 | WP_001058486.1 | hypothetical protein | Antitoxin |
| HLV54_RS04145 (HLV54_000829) | 876251..876571 | + | 321 | WP_001103942.1 | DUF1474 family protein | Toxin |
| HLV54_RS04150 (HLV54_000830) | 876635..877504 | + | 870 | WP_001002732.1 | primase alpha helix C-terminal domain-containing protein | - |
| HLV54_RS04155 (HLV54_000831) | 877521..878990 | + | 1470 | WP_000390454.1 | virulence-associated E family protein | - |
| HLV54_RS04160 (HLV54_000832) | 879276..879638 | + | 363 | WP_001039168.1 | hypothetical protein | - |
| HLV54_RS04165 (HLV54_000833) | 879640..879924 | + | 285 | WP_000998181.1 | hypothetical protein | - |
| HLV54_RS04170 (HLV54_000834) | 879921..880562 | + | 642 | WP_001019764.1 | hypothetical protein | - |
| HLV54_RS04175 (HLV54_000835) | 881079..881420 | + | 342 | WP_001190615.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | selk / selq / seb | 853024..886371 | 33347 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 107 a.a. Molecular weight: 12694.22 Da Isoelectric Point: 4.7419
>T212350 WP_001103942.1 NZ_CP080770:876251-876571 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLHVYLKEFSELIQKF
HEIEKASSENFDEESDDAKNSIKVAE
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLHVYLKEFSELIQKF
HEIEKASSENFDEESDDAKNSIKVAE
Download Length: 321 bp
>T212350 NZ_CP107003:c4119378-4119028 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACACGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACACGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA
Antitoxin
Download Length: 70 a.a. Molecular weight: 8252.31 Da Isoelectric Point: 4.3718
>AT212350 WP_001058486.1 NZ_CP080770:876039-876248 [Staphylococcus aureus]
MNNEQKEVIEHLVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE
MNNEQKEVIEHLVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE
Download Length: 210 bp
>AT212350 NZ_CP107003:c4119623-4119372 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|