Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 472284..472902 Replicon chromosome
Accession NC_007384
Organism Shigella sonnei Ss046

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag SSON_RS02400 Protein ID WP_001291435.1
Coordinates 472284..472502 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag SSON_RS02405 Protein ID WP_000344800.1
Coordinates 472528..472902 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SSON_RS02370 (467576) 467576..468148 + 573 WP_000779812.1 YbaY family lipoprotein -
SSON_RS02375 (468179) 468179..468490 - 312 WP_000409911.1 MGMT family protein -
SSON_RS02380 (468869) 468869..469222 + 354 WP_000878140.1 DUF1428 domain-containing protein -
SSON_RS02385 (469264) 469264..470812 - 1549 Protein_441 cyclic-guanylate-specific phosphodiesterase PdeB -
SSON_RS02390 (470976) 470976..471446 - 471 WP_000136192.1 YlaC family protein -
SSON_RS02395 (471562) 471562..472113 - 552 WP_000102564.1 maltose O-acetyltransferase -
SSON_RS02400 (472284) 472284..472502 - 219 WP_001291435.1 HHA domain-containing protein Toxin
SSON_RS02405 (472528) 472528..472902 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
SSON_RS02410 (473448) 473448..476597 - 3150 WP_001132464.1 efflux RND transporter permease AcrB -
SSON_RS02415 (476620) 476620..477813 - 1194 WP_011310152.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T21235 WP_001291435.1 NC_007384:c472502-472284 [Shigella sonnei Ss046]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T21235 NC_007384:c472502-472284 [Shigella sonnei Ss046]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTATACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT21235 WP_000344800.1 NC_007384:c472902-472528 [Shigella sonnei Ss046]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT21235 NC_007384:c472902-472528 [Shigella sonnei Ss046]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References