Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TsaAT/- |
| Location | 858344..858821 | Replicon | chromosome |
| Accession | NZ_CP080770 | ||
| Organism | Staphylococcus aureus strain HL23187 | ||
Toxin (Protein)
| Gene name | TsaT | Uniprot ID | T1Y7S2 |
| Locus tag | HLV54_RS04000 | Protein ID | WP_000052076.1 |
| Coordinates | 858344..858532 (-) | Length | 63 a.a. |
Antitoxin (Protein)
| Gene name | TsaA | Uniprot ID | T1Y6P8 |
| Locus tag | HLV54_RS04005 | Protein ID | WP_001059690.1 |
| Coordinates | 858561..858821 (-) | Length | 87 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HLV54_RS03970 (HLV54_000794) | 854382..854852 | + | 471 | WP_000824462.1 | hypothetical protein | - |
| HLV54_RS03975 (HLV54_000795) | 855193..855879 | + | 687 | WP_001823812.1 | thermonuclease family protein | - |
| HLV54_RS03980 (HLV54_000796) | 856236..856436 | + | 201 | WP_001059082.1 | cold-shock protein | - |
| HLV54_RS03985 (HLV54_000797) | 856935..857153 | - | 219 | WP_000005888.1 | hypothetical protein | - |
| HLV54_RS03990 (HLV54_000798) | 857215..857499 | - | 285 | WP_001004397.1 | hypothetical protein | - |
| HLV54_RS03995 (HLV54_000799) | 857587..858156 | - | 570 | WP_001106657.1 | lipoprotein N-acylation protein LnsA | - |
| HLV54_RS04000 (HLV54_000800) | 858344..858532 | - | 189 | WP_000052076.1 | hypothetical protein | Toxin |
| HLV54_RS04005 (HLV54_000801) | 858561..858821 | - | 261 | WP_001059690.1 | hypothetical protein | Antitoxin |
| HLV54_RS04010 (HLV54_000802) | 859162..859365 | + | 204 | WP_000145163.1 | sterile alpha motif-like domain-containing protein | - |
| HLV54_RS04015 (HLV54_000803) | 859362..859598 | - | 237 | WP_000368687.1 | hypothetical protein | - |
| HLV54_RS04020 (HLV54_000804) | 859823..860404 | + | 582 | WP_001140697.1 | histidine phosphatase family protein | - |
| HLV54_RS04025 (HLV54_000805) | 860477..861094 | - | 618 | WP_000255554.1 | LysE/ArgO family amino acid transporter | - |
| HLV54_RS04030 (HLV54_000806) | 861250..861744 | - | 495 | WP_000569881.1 | GNAT family N-acetyltransferase | - |
| HLV54_RS04035 (HLV54_000807) | 862143..862565 | - | 423 | WP_000974455.1 | organic hydroperoxide resistance protein | - |
| HLV54_RS04040 (HLV54_000808) | 862713..863429 | + | 717 | WP_000150029.1 | type I 3-dehydroquinate dehydratase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | selk / selq / seb | 853024..886371 | 33347 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 63 a.a. Molecular weight: 7142.82 Da Isoelectric Point: 9.9971
>T212349 WP_000052076.1 NZ_CP080770:c858532-858344 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL
Download Length: 189 bp
>T212349 NZ_CP107003:4032571-4032828 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA
Antitoxin
Download Length: 87 a.a. Molecular weight: 9940.09 Da Isoelectric Point: 4.0624
>AT212349 WP_001059690.1 NZ_CP080770:c858821-858561 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG
Download Length: 261 bp
>AT212349 NZ_CP107003:4032840-4033385 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E0VP18 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E0VN56 |