Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 16579..17219 Replicon plasmid p2
Accession NZ_CP080769
Organism Cupriavidus pinatubonensis strain HN-2

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag K2O51_RS31985 Protein ID WP_220632162.1
Coordinates 16579..16980 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag K2O51_RS31990 Protein ID WP_220632163.1
Coordinates 16977..17219 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K2O51_RS31970 (K2O51_31970) 12312..13334 + 1023 WP_220632160.1 tripartite tricarboxylate transporter substrate binding protein -
K2O51_RS31975 (K2O51_31975) 13287..13991 - 705 WP_220632161.1 hypothetical protein -
K2O51_RS31980 (K2O51_31980) 14341..16029 - 1689 WP_220632290.1 SulP family inorganic anion transporter -
K2O51_RS31985 (K2O51_31985) 16579..16980 - 402 WP_220632162.1 type II toxin-antitoxin system VapC family toxin Toxin
K2O51_RS31990 (K2O51_31990) 16977..17219 - 243 WP_220632163.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
K2O51_RS31995 (K2O51_31995) 18337..18609 + 273 WP_245002062.1 hypothetical protein -
K2O51_RS32000 (K2O51_32000) 18578..18826 - 249 Protein_17 transposase -
K2O51_RS32005 (K2O51_32005) 18952..19344 - 393 WP_140953127.1 phage integrase family protein -
K2O51_RS32010 (K2O51_32010) 19508..19657 - 150 WP_220632164.1 hypothetical protein -
K2O51_RS32015 (K2O51_32015) 19862..20776 + 915 WP_220632165.1 oxygenase MpaB family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - gmd / adeG 1..689000 689000


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-121)

Antitoxin

SpoVT-AbrB domain

(7-46)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14659.83 Da        Isoelectric Point: 6.6448

>T212348 WP_220632162.1 NZ_CP080769:c16980-16579 [Cupriavidus pinatubonensis]
MKYLLDANAVIAMLKGERIMLERLRAHLPTDFGLPSIVAHELYYGAYKSQRAVANLARIEALQFEVVPFDAEDAQHAGEI
RAQLAAAGTPIGPYDVLIAGQARARNLILVTHNVREFARVAQLNVEDWHAGGQ

Download         Length: 402 bp

>T212348 NZ_CP107003:3759975-3760253 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8929.09 Da        Isoelectric Point: 4.7628

>AT212348 WP_220632163.1 NZ_CP080769:c17219-16977 [Cupriavidus pinatubonensis]
MEFAKVFRHGGSQAVRLPKDYRFDTAEVRIRRHGAAVILEPVPQDWAWLAPLVGPVDADFESAAVAQPEAQERPGLDVFE

Download         Length: 243 bp

>AT212348 NZ_CP107003:3759712-3759972 [Escherichia coli]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCAGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCATTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References