Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 3885270..3885958 Replicon chromosome
Accession NZ_CP080767
Organism Cupriavidus pinatubonensis strain HN-2

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag K2O51_RS30710 Protein ID WP_220631162.1
Coordinates 3885524..3885958 (+) Length 145 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag K2O51_RS30705 Protein ID WP_011299580.1
Coordinates 3885270..3885527 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K2O51_RS30675 (K2O51_30675) 3880609..3881583 + 975 WP_140950448.1 M14 family metallopeptidase -
K2O51_RS30680 (K2O51_30680) 3881588..3882166 - 579 WP_140950449.1 Sbal_3080 family lipoprotein -
K2O51_RS30685 (K2O51_30685) 3882322..3882522 - 201 WP_041679762.1 hypothetical protein -
K2O51_RS30690 (K2O51_30690) 3882531..3883100 - 570 WP_011299577.1 OB-fold putative lipoprotein -
K2O51_RS30695 (K2O51_30695) 3883146..3884390 - 1245 WP_220631160.1 glycosyltransferase -
K2O51_RS30700 (K2O51_30700) 3884562..3885176 + 615 WP_220631161.1 HAD family phosphatase -
K2O51_RS30705 (K2O51_30705) 3885270..3885527 + 258 WP_011299580.1 plasmid stabilization protein Antitoxin
K2O51_RS30710 (K2O51_30710) 3885524..3885958 + 435 WP_220631162.1 type II toxin-antitoxin system VapC family toxin Toxin
K2O51_RS30715 (K2O51_30715) 3886082..3887509 - 1428 WP_011299582.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE -
K2O51_RS30720 (K2O51_30720) 3887606..3888403 - 798 WP_220631163.1 CHAD domain-containing protein -
K2O51_RS30725 (K2O51_30725) 3888565..3889002 + 438 WP_220631164.1 PaaI family thioesterase -
K2O51_RS30730 (K2O51_30730) 3889075..3889845 - 771 WP_220631165.1 trans-aconitate 2-methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15243.50 Da        Isoelectric Point: 4.7237

>T212347 WP_220631162.1 NZ_CP080767:3885524-3885958 [Cupriavidus pinatubonensis]
MIVLDTNVVSEAMKPEPAATVRAWLDEQVAETLYLSSVSLAELLYGIACLPDGRRKLALEDALEGLMALFAGRVLPFDPG
AARCYAELAAKARAAGKGFPTPDGYIAAIATAHGFTVASRDTAPFEAAGVPVIDPWHCGREAQR

Download         Length: 435 bp

>T212347 NZ_CP107003:c3753913-3753515 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCCTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGAGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGGGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9459.70 Da        Isoelectric Point: 9.1613

>AT212347 WP_011299580.1 NZ_CP080767:3885270-3885527 [Cupriavidus pinatubonensis]
MATLTIRNLPDETHRALRVQAAAHGRSTEAEVRDILARAVNPPERVKMGEALAQLGRRLGLTNADVEALEQTRDRTPAQP
PRFHE

Download         Length: 258 bp

>AT212347 NZ_CP107003:c3754209-3753916 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References