Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PP_4151-4152/excise(antitoxin) |
| Location | 1356085..1357127 | Replicon | chromosome |
| Accession | NZ_CP080761 | ||
| Organism | Diaphorobacter sp. MNS-0 | ||
Toxin (Protein)
| Gene name | PP_4152 | Uniprot ID | - |
| Locus tag | K2L43_RS06500 | Protein ID | WP_003153636.1 |
| Coordinates | 1356552..1357127 (+) | Length | 192 a.a. |
Antitoxin (Protein)
| Gene name | PP_4151 | Uniprot ID | I3TV68 |
| Locus tag | K2L43_RS06495 | Protein ID | WP_003050245.1 |
| Coordinates | 1356085..1356555 (+) | Length | 157 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K2L43_RS06460 (K2L43_06460) | 1351468..1352898 | - | 1431 | WP_011804670.1 | TIGR03752 family integrating conjugative element protein | - |
| K2L43_RS06465 (K2L43_06465) | 1352888..1353796 | - | 909 | WP_009516219.1 | TIGR03749 family integrating conjugative element protein | - |
| K2L43_RS06470 (K2L43_06470) | 1353793..1354485 | - | 693 | WP_009516220.1 | TIGR03746 family integrating conjugative element protein | - |
| K2L43_RS06475 (K2L43_06475) | 1354482..1354880 | - | 399 | WP_009516221.1 | TIGR03750 family conjugal transfer protein | - |
| K2L43_RS06480 (K2L43_06480) | 1354892..1355251 | - | 360 | WP_003090173.1 | TIGR03745 family integrating conjugative element membrane protein | - |
| K2L43_RS06485 (K2L43_06485) | 1355268..1355501 | - | 234 | WP_003050225.1 | TIGR03758 family integrating conjugative element protein | - |
| K2L43_RS06490 (K2L43_06490) | 1355498..1355881 | - | 384 | WP_011804671.1 | RAQPRD family integrative conjugative element protein | - |
| K2L43_RS06495 (K2L43_06495) | 1356085..1356555 | + | 471 | WP_003050245.1 | helix-turn-helix domain-containing protein | Antitoxin |
| K2L43_RS06500 (K2L43_06500) | 1356552..1357127 | + | 576 | WP_003153636.1 | PIN domain-containing protein | Toxin |
| K2L43_RS06505 (K2L43_06505) | 1357145..1358059 | + | 915 | WP_003050256.1 | AAA family ATPase | - |
| K2L43_RS06510 (K2L43_06510) | 1358056..1358526 | + | 471 | WP_011804672.1 | type III CBASS phage resistance system CD-NTase-associated protein Cap8 | - |
| K2L43_RS06515 (K2L43_06515) | 1358523..1359023 | + | 501 | WP_011804673.1 | type III CBASS phage resistance system CD-NTase-associated protein Cap7 | - |
| K2L43_RS06520 (K2L43_06520) | 1359023..1359925 | + | 903 | WP_220638723.1 | CBASS oligonucleotide cyclase | - |
| K2L43_RS06525 (K2L43_06525) | 1359964..1360689 | + | 726 | WP_003050273.1 | CBASS effector endonuclease NucC | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | - | 1304449..1379142 | 74693 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 192 a.a. Molecular weight: 21629.78 Da Isoelectric Point: 5.9995
>T212345 WP_003153636.1 NZ_CP080761:1356552-1357127 [Diaphorobacter sp. MNS-0]
MRHSPFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSQAIHEEWKRNLLINRPDLTRVQVDRTSDLMDRAIPDGLVEGY
EALVAGLTLPDPNDRHVLAAAIRCGASVIVTFNERDFPNDLLAPYGIESQHPDEFVDNLLDLDAAAVVSAAQRQRAQLKH
PPIDVDRYLEILLRQGLVQTTKVLATYRTIL
MRHSPFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSQAIHEEWKRNLLINRPDLTRVQVDRTSDLMDRAIPDGLVEGY
EALVAGLTLPDPNDRHVLAAAIRCGASVIVTFNERDFPNDLLAPYGIESQHPDEFVDNLLDLDAAAVVSAAQRQRAQLKH
PPIDVDRYLEILLRQGLVQTTKVLATYRTIL
Download Length: 576 bp
>T212345 NZ_CP107003:3561455-3561673 [Escherichia coli]
ATGTCCGAAAAATTTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA
ATGTCCGAAAAATTTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA
Antitoxin
Download Length: 157 a.a. Molecular weight: 17245.62 Da Isoelectric Point: 6.3803
>AT212345 WP_003050245.1 NZ_CP080761:1356085-1356555 [Diaphorobacter sp. MNS-0]
MTTATAQSKMTLPAAGEVKAAVQGQRALAAYLATQFETQHIQIFDDHKQAHQVELPTSALRLLVDILAELADGNAVKVVP
VHAELTTQEAADLLNVSRPHFVKLLEDGVLAFHRTGKHRRVRFADLMQYKEARERASEQAMAELAQQSQELGMGYE
MTTATAQSKMTLPAAGEVKAAVQGQRALAAYLATQFETQHIQIFDDHKQAHQVELPTSALRLLVDILAELADGNAVKVVP
VHAELTTQEAADLLNVSRPHFVKLLEDGVLAFHRTGKHRRVRFADLMQYKEARERASEQAMAELAQQSQELGMGYE
Download Length: 471 bp
>AT212345 NZ_CP107003:3561055-3561429 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|