Detailed information of TA system TA021234

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): itaRT/DUF1778(antitoxin)
• Location: 434588..435425
• Replicon: chromosome
• Accession: NC_007384
• Organism: Shigella sonnei Ss046

Toxin (Protein)

• Gene name: itaT
• Uniprot ID: Q3Z4X7
• Locus tag: SSON_RS02200
• Protein ID: WP_000227784.1
• Coordinates: 434588..435130 (-)
• Length: 181 a.a.

Antitoxin (Protein)

• Gene name: itaR
• Uniprot ID: I2UQS9
• Locus tag: SSON_RS02205
• Protein ID: WP_001297137.1
• Coordinates: 435114..435425 (-)
• Length: 104 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SSON_RS02170 (429652)	429652..430143	+	492	WP_001138904.1	nucleotide binding protein YajQ	-
SSON_RS02175 (430271)	430271..431635	-	1365	WP_001000971.1	MFS transporter	-
SSON_RS02180 (431754)	431754..432451	+	698	WP_237158184.1	IS1-like element IS1A family transposase	-
SSON_RS02185 (432820)	432820..433218	+	399	Protein_403	SEL1-like repeat protein	-
SSON_RS02195 (433966)	433966..434532	+	567	Protein_405	SEL1-like repeat protein	-
SSON_RS02200 (434588)	434588..435130	-	543	WP_000227784.1	GNAT family N-acetyltransferase	Toxin
SSON_RS02205 (435114)	435114..435425	-	312	WP_001297137.1	DUF1778 domain-containing protein	Antitoxin
SSON_RS02210 (435610)	435610..436500	-	891	WP_000971327.1	heme o synthase	-
SSON_RS02215 (436512)	436512..436841	-	330	WP_000019869.1	cytochrome o ubiquinol oxidase subunit IV	-
SSON_RS02220 (436841)	436841..437455	-	615	WP_000179819.1	cytochrome o ubiquinol oxidase subunit III	-
SSON_RS02225 (437445)	437445..439436	-	1992	WP_000467180.1	cytochrome o ubiquinol oxidase subunit I	-
SSON_RS02230 (439458)	439458..440405	-	948	WP_001239441.1	cytochrome o ubiquinol oxidase subunit II	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (68-156)

Antitoxin

• Vibrio phage ICP1, Orf50 (14-97)

Sequences

Toxin

Protein

• Length: 181 a.a.
• Molecular weight: 19805.02 Da
• Isoelectric Point: 8.3395

>T21234 WP_000227784.1 NC_007384:c435130-434588 [Shigella sonnei Ss046]
MVDKHEEITLPIVLSCNYQSDITYPGQKQFDCGNPVIDKFVRASLKKSVRNSDCAAKALIDRQSGELIGICTFTAYSLEK
QRVSGVLQGSQPSEIGVVRLVMLGVARKYQKRGFGQDLLCDFFEHVKIIHQALPIKGVYLDADPAAINFYARLGFVQLSA
TPNAFGAVPMFLAIQHILAA

Nucleotide

• Length: 543 bp

>T21234 NC_007384:c435130-434588 [Shigella sonnei Ss046]
ATGGTCGACAAGCATGAAGAGATTACTCTGCCCATAGTCCTCTCCTGTAATTATCAGTCTGATATTACTTATCCTGGGCA
AAAACAGTTTGATTGCGGTAACCCTGTTATCGATAAATTTGTACGCGCATCGCTAAAGAAAAGTGTGCGTAATAGCGACT
GTGCGGCTAAAGCACTTATTGACAGACAAAGTGGTGAACTGATCGGCATCTGTACTTTTACGGCATATTCGCTGGAAAAA
CAACGCGTTTCTGGCGTCCTTCAGGGTTCACAACCTTCAGAAATTGGTGTTGTCAGATTAGTCATGTTGGGGGTAGCACG
GAAGTATCAAAAGCGGGGCTTTGGTCAGGACCTACTATGTGATTTTTTTGAACATGTAAAAATAATTCACCAGGCATTAC
CAATTAAAGGGGTTTATCTTGATGCTGACCCTGCCGCCATTAATTTTTATGCTCGTCTCGGCTTTGTTCAGCTTTCAGCG
ACACCAAATGCTTTTGGTGCTGTACCTATGTTTTTGGCGATTCAGCATATTCTCGCGGCTTAG

Antitoxin

Protein

• Length: 104 a.a.
• Molecular weight: 11358.04 Da
• Isoelectric Point: 10.4825

>AT21234 WP_001297137.1 NC_007384:c435425-435114 [Shigella sonnei Ss046]
MPGKTATLPDVDKTLKNARVELKTSPDAKNKLREAAQAVGVDLSAFILSAAMERAESVLDNQRRRELSNQSWELMNQLIA
EPAQPTLALKALMKRKNSDGRQA

Nucleotide

• Length: 312 bp

>AT21234 NC_007384:c435425-435114 [Shigella sonnei Ss046]
ATGCCTGGAAAAACAGCCACTCTACCCGATGTCGATAAAACGCTGAAAAATGCGCGGGTCGAACTCAAAACTAGTCCCGA
CGCCAAAAACAAACTTCGTGAAGCTGCGCAAGCCGTTGGGGTAGATTTAAGCGCTTTTATTTTGAGCGCTGCTATGGAAC
GCGCCGAAAGTGTGCTTGATAACCAACGTCGCCGTGAGCTTTCGAATCAAAGCTGGGAACTGATGAACCAACTCATCGCT
GAACCTGCTCAACCGACGCTCGCCCTCAAGGCGTTAATGAAAAGGAAAAACAGCGATGGTCGACAAGCATGA

Structures

Toxin

• PDB: 7BYY

Antitoxin

• AlphaFold DB: A0A0E0Y6B3