Detailed information of TA system TA212324

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 1277643..1278279
• Replicon: chromosome
• Accession: NZ_CP080636
• Organism: Acinetobacter lwoffii strain EK30A

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: N9R2M8
• Locus tag: ABEKA_RS07550
• Protein ID: WP_004732265.1
• Coordinates: 1277893..1278279 (+)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: N9NUN9
• Locus tag: ABEKA_RS07545
• Protein ID: WP_004281484.1
• Coordinates: 1277643..1277900 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ABEKA_RS07525 (ABEKA_1266)	1273126..1274133	+	1008	WP_004281489.1	DNA-directed RNA polymerase subunit alpha	-
ABEKA_RS07530 (ABEKA_1267)	1274152..1274517	+	366	WP_004281488.1	50S ribosomal protein L17	-
ABEKA_RS07535 (ABEKA_1268)	1274735..1276225	+	1491	WP_004732270.1	NAD(P)/FAD-dependent oxidoreductase	-
ABEKA_RS07540 (ABEKA_1269)	1276286..1277458	-	1173	WP_004732268.1	acyl-CoA dehydrogenase family protein	-
ABEKA_RS07545 (ABEKA_1270)	1277643..1277900	+	258	WP_004281484.1	succinate dehydrogenase assembly factor 2	Antitoxin
ABEKA_RS07550 (ABEKA_1271)	1277893..1278279	+	387	WP_004732265.1	hypothetical protein	Toxin
ABEKA_RS07555 (ABEKA_1272)	1278815..1279855	+	1041	WP_004732263.1	hypothetical protein	-
ABEKA_RS07560 (ABEKA_1273)	1279923..1280495	+	573	WP_004732261.1	rhombosortase	-
ABEKA_RS07565 (ABEKA_1274)	1280693..1282975	+	2283	WP_168387020.1	TRAP transporter large permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-80)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 15229.34 Da
• Isoelectric Point: 9.9707

>T212324 WP_004732265.1 NZ_CP080636:1277893-1278279 [Acinetobacter lwoffii]
MDNRCFKLKRSLCALAFQLFIFALLMYLLYQLLPIALWAVCAVIGLVIYQLFYRKTPQIEQFEYLDGREWSLTAKARSTR
RVCISHVIDHQAYIVVYFQHAKARPLLIWCDQLPFKQWKSLKLLTKLI

Nucleotide

• Length: 387 bp

>T212324 NZ_CP107002:3759975-3760253 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10340.82 Da
• Isoelectric Point: 4.6051

>AT212324 WP_004281484.1 NZ_CP080636:1277643-1277900 [Acinetobacter lwoffii]
MTDDISLEERKVIYRARRGLKELDVYFDPYVKNHYLNAEPFEKQMFAELVEQEDPDLLDWFMEVSEPPRPELKDFIKKLK
FYVHG

Nucleotide

• Length: 258 bp

>AT212324 NZ_CP107002:3759712-3759972 [Escherichia coli]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCAGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCATTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Structures

Toxin

• AlphaFold DB: N9R2M8

Antitoxin

• AlphaFold DB: N9NUN9