212323

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /DUF1778(antitoxin)
Location 4231306..4232102 Replicon chromosome
Accession NZ_CP080635
Organism Shewanella putrefaciens strain YZ-J

Toxin (Protein)


Gene name - Uniprot ID A0A6N3J9I8
Locus tag K3G22_RS18755 Protein ID WP_011791158.1
Coordinates 4231306..4231836 (-) Length 177 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A6N3J9J2
Locus tag K3G22_RS18760 Protein ID WP_011791159.1
Coordinates 4231833..4232102 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K3G22_RS18735 (K3G22_18735) 4227846..4228613 - 768 WP_011791154.1 class I SAM-dependent methyltransferase -
K3G22_RS18740 (K3G22_18740) 4228888..4229661 + 774 WP_011791155.1 hypothetical protein -
K3G22_RS18745 (K3G22_18745) 4229936..4230406 + 471 WP_011791156.1 hypothetical protein -
K3G22_RS18750 (K3G22_18750) 4230556..4230897 + 342 WP_229781437.1 hypothetical protein -
K3G22_RS18755 (K3G22_18755) 4231306..4231836 - 531 WP_011791158.1 GNAT family N-acetyltransferase Toxin
K3G22_RS18760 (K3G22_18760) 4231833..4232102 - 270 WP_011791159.1 DUF1778 domain-containing protein Antitoxin
K3G22_RS18765 (K3G22_18765) 4232479..4233033 - 555 WP_025007978.1 transglycosylase domain-containing protein -
K3G22_RS18770 (K3G22_18770) 4233409..4233633 - 225 WP_025007977.1 hypothetical protein -
K3G22_RS18775 (K3G22_18775) 4233989..4234681 - 693 WP_025007976.1 hypothetical protein -
K3G22_RS18780 (K3G22_18780) 4235189..4235572 - 384 WP_011791162.1 GIY-YIG nuclease family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(97-153)

Antitoxin

Vibrio phage ICP1, Orf50

(5-81)


Sequences

Toxin        


Download         Length: 177 a.a.        Molecular weight: 19795.16 Da        Isoelectric Point: 8.3330

>T212323 WP_011791158.1 NZ_CP080635:c4231836-4231306 [Shewanella putrefaciens]
VSYSKIFKELDKSLHDRVSFDCGEAELNDFIQTQAAKHMQAGISRTMVLPAAMPLPNQKYPICSFYTIAPSSICRDTLPQ
AIGKKLPRYPIPVFLLAQLAVHKEFHGSGLGKASLIKALEYLWEINAHMRAYAIVVDCLTDQAESFYAKYGFEVLCEING
RVRMFIPMKTVGQLFT

Download         Length: 531 bp

>T212323 NZ_CP107002:c3753913-3753515 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCCTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGAGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGGGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9859.32 Da        Isoelectric Point: 4.7037

>AT212323 WP_011791159.1 NZ_CP080635:c4232102-4231833 [Shewanella putrefaciens]
MATARLDIRLDEEIKAKAEKASALLGLKSLTEYVVRLMDEDATQVIAEHESVTVKADVFDQFIMACDEAKVPNKALREAA
AFTKNGEFK

Download         Length: 270 bp

>AT212323 NZ_CP107002:c3754209-3753916 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6N3J9I8

Antitoxin

Source ID Structure
AlphaFold DB A0A6N3J9J2

References