Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /DUF1778(antitoxin) |
| Location | 799448..800244 | Replicon | chromosome |
| Accession | NZ_CP080633 | ||
| Organism | Shewanella putrefaciens strain YZ08 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | - |
| Locus tag | K2227_RS03610 | Protein ID | WP_220591991.1 |
| Coordinates | 799714..800244 (+) | Length | 177 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | B8ECY1 |
| Locus tag | K2227_RS03605 | Protein ID | WP_012586779.1 |
| Coordinates | 799448..799717 (+) | Length | 90 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K2227_RS03570 (K2227_03570) | 794506..795180 | + | 675 | WP_220591984.1 | Fe2+-dependent dioxygenase | - |
| K2227_RS03575 (K2227_03575) | 795617..796102 | + | 486 | WP_220591985.1 | hypothetical protein | - |
| K2227_RS03580 (K2227_03580) | 796257..796907 | + | 651 | WP_259400068.1 | hypothetical protein | - |
| K2227_RS03585 (K2227_03585) | 797058..797636 | + | 579 | WP_220591987.1 | hypothetical protein | - |
| K2227_RS03590 (K2227_03590) | 797809..798186 | + | 378 | WP_220591988.1 | hypothetical protein | - |
| K2227_RS03595 (K2227_03595) | 798386..798790 | + | 405 | WP_220591989.1 | hypothetical protein | - |
| K2227_RS03600 (K2227_03600) | 798925..799281 | + | 357 | WP_220591990.1 | hypothetical protein | - |
| K2227_RS03605 (K2227_03605) | 799448..799717 | + | 270 | WP_012586779.1 | DUF1778 domain-containing protein | Antitoxin |
| K2227_RS03610 (K2227_03610) | 799714..800244 | + | 531 | WP_220591991.1 | GNAT family N-acetyltransferase | Toxin |
| K2227_RS03615 (K2227_03615) | 800628..801179 | + | 552 | WP_220591992.1 | tetratricopeptide repeat protein | - |
| K2227_RS03620 (K2227_03620) | 801262..801546 | + | 285 | WP_220591993.1 | hypothetical protein | - |
| K2227_RS03625 (K2227_03625) | 801651..801974 | + | 324 | WP_220591994.1 | hypothetical protein | - |
| K2227_RS03630 (K2227_03630) | 802042..802362 | - | 321 | WP_220591995.1 | hypothetical protein | - |
| K2227_RS03635 (K2227_03635) | 802359..802590 | - | 232 | Protein_706 | hypothetical protein | - |
| K2227_RS03640 (K2227_03640) | 802587..802850 | - | 264 | WP_220591996.1 | hypothetical protein | - |
| K2227_RS03645 (K2227_03645) | 802851..803144 | - | 294 | WP_012088260.1 | hypothetical protein | - |
| K2227_RS03650 (K2227_03650) | 803141..803839 | - | 699 | WP_220591997.1 | hypothetical protein | - |
| K2227_RS03655 (K2227_03655) | 803836..804426 | - | 591 | WP_220591998.1 | ead/Ea22-like family protein | - |
| K2227_RS03660 (K2227_03660) | 804437..804601 | - | 165 | WP_006083880.1 | hypothetical protein | - |
| K2227_RS03665 (K2227_03665) | 804626..804973 | - | 348 | WP_011847795.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 788043..855692 | 67649 | |
| - | inside | Integron | - | - | 797058..801974 | 4916 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 177 a.a. Molecular weight: 19759.02 Da Isoelectric Point: 8.4733
>T212318 WP_220591991.1 NZ_CP080633:799714-800244 [Shewanella putrefaciens]
VSYSKTFKELDKSQHDRASFDCGEAELNDFIQTQAAKHMQAGISRTMVLPACTPLPNQKYPICSFYTIAPSSICRDTLPQ
AMGKKLPRYPIPVFLLAQLAVHKEFHGNGLGKASLIKALEYLWEINAHMRAYAIVVDCLTGQAESFYAKYGFEVLCEING
RVRMFIPMKTVGQLFT
VSYSKTFKELDKSQHDRASFDCGEAELNDFIQTQAAKHMQAGISRTMVLPACTPLPNQKYPICSFYTIAPSSICRDTLPQ
AMGKKLPRYPIPVFLLAQLAVHKEFHGNGLGKASLIKALEYLWEINAHMRAYAIVVDCLTGQAESFYAKYGFEVLCEING
RVRMFIPMKTVGQLFT
Download Length: 531 bp
>T212318 NZ_CP107002:c2382413-2382237 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA
Antitoxin
Download Length: 90 a.a. Molecular weight: 9903.38 Da Isoelectric Point: 4.9059
>AT212318 WP_012586779.1 NZ_CP080633:799448-799717 [Shewanella putrefaciens]
MATARLDIRLDEEIKAKAEKASALLGLKSLTEYVVRLMDEDSTQVIAEHESITVKADVFDQFIMACDEAKAPNKALREAA
AFTKRGEFK
MATARLDIRLDEEIKAKAEKASALLGLKSLTEYVVRLMDEDSTQVIAEHESITVKADVFDQFIMACDEAKAPNKALREAA
AFTKRGEFK
Download Length: 270 bp
>AT212318 NZ_CP107002:c2382191-2381775 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|