212315

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 4503537..4505110 Replicon chromosome
Accession NZ_CP080630
Organism Aeromonas veronii strain A29V

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag K3G24_RS20725 Protein ID WP_042864682.1
Coordinates 4503537..4504856 (-) Length 440 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag K3G24_RS20730 Protein ID WP_017410478.1
Coordinates 4504856..4505110 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K3G24_RS20710 (K3G24_20695) 4499454..4500218 + 765 WP_107683436.1 ATP-binding cassette domain-containing protein -
K3G24_RS20715 (K3G24_20700) 4500253..4501137 + 885 WP_107683435.1 ABC transporter substrate-binding protein -
K3G24_RS20720 (K3G24_20705) 4501134..4503116 + 1983 WP_236095657.1 Fe(3+)-hydroxamate ABC transporter permease FhuB -
K3G24_RS20725 (K3G24_20710) 4503537..4504856 - 1320 WP_042864682.1 type II toxin-antitoxin system HipA family toxin Toxin
K3G24_RS20730 (K3G24_20715) 4504856..4505110 - 255 WP_017410478.1 helix-turn-helix domain-containing protein Antitoxin
K3G24_RS20735 (K3G24_20720) 4505648..4506265 + 618 WP_107683433.1 recombinase family protein -
K3G24_RS20740 (K3G24_20725) 4506262..4506585 - 324 WP_021231525.1 hypothetical protein -
K3G24_RS20745 (K3G24_20730) 4507324..4509789 + 2466 WP_107683432.1 DEAD/DEAH box helicase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 440 a.a.        Molecular weight: 49588.58 Da        Isoelectric Point: 6.8291

>T212315 WP_042864682.1 NZ_CP080630:c4504856-4503537 [Aeromonas veronii]
MANLAVYMNGYRVGTFTKTTSGAHQFQYHESWLAQPGSRPISLSMPLRHQAYRGDEAYNFFDNLLPDNTEVRNRVVARYQ
AASTQPFDLLSCIGQDSVGALQLVTEGHDVPDVRRIDYKALSDDELEQILTSYKSGIPLGMVREQEEFRISIAGAQEKTA
LLYIDGRWYLPLKATPTTHIIKLPIGKIESHSYSIDLSQSVENEYLCTLIAKEFGLPVPHCFMMQVGQVKALAVERFDRR
YAADRSWIMRLPQEDFCQVLNVPSARKYESHGGPGITDIMKTLLGSATPEQDRYLFMKSQVLFWLLAATDGHAKNFSVFI
EPEGRFRLTPFYDILSVYPVFGGRGLNRRDAKLAMGLASSKGKKYSIEQIFPRHFFQTAKTVGFERSAMEEILTELANSV
DDVIERVTQQLPADFPDTISSTILEGLKARSARLIKGWD

Download         Length: 1320 bp

>T212315 NZ_CP107002:1967178-1967281 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9293.62 Da        Isoelectric Point: 7.9834

>AT212315 WP_017410478.1 NZ_CP080630:c4505110-4504856 [Aeromonas veronii]
MKVTSAKQLSACIKDARLSQKLSQGKVAEKVGIRQDTVSSFELNPESTKLETLFKILAALELSVDIKPRNESSESPASGW
KEEW

Download         Length: 255 bp

>AT212315 NZ_CP107002:c1967319-1967048 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References