Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-yefM/YoeB-RelB
Location 707570..708080 Replicon chromosome
Accession NZ_CP080627
Organism Halomonas qaidamensis strain XH36

Toxin (Protein)


Gene name relB Uniprot ID A0A3S8YP06
Locus tag K1Y77_RS03345 Protein ID WP_030069596.1
Coordinates 707817..708080 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A7C9NMR2
Locus tag K1Y77_RS03340 Protein ID WP_030069594.1
Coordinates 707570..707824 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K1Y77_RS03325 (K1Y77_03320) 704458..705087 + 630 WP_264430324.1 hypothetical protein -
K1Y77_RS03330 (K1Y77_03325) 705084..706313 + 1230 WP_264430326.1 hypothetical protein -
K1Y77_RS03335 (K1Y77_03330) 706310..707176 + 867 WP_030069592.1 hypothetical protein -
K1Y77_RS03340 (K1Y77_03335) 707570..707824 + 255 WP_030069594.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
K1Y77_RS03345 (K1Y77_03340) 707817..708080 + 264 WP_030069596.1 Txe/YoeB family addiction module toxin Toxin
K1Y77_RS03350 (K1Y77_03345) 708279..708557 + 279 WP_030069598.1 type II toxin-antitoxin system RelE/ParE family toxin -
K1Y77_RS03355 (K1Y77_03350) 708557..708850 + 294 WP_030069600.1 HigA family addiction module antitoxin -
K1Y77_RS03360 (K1Y77_03355) 708969..709931 + 963 WP_264430333.1 ribonuclease Z -
K1Y77_RS03365 (K1Y77_03360) 710043..710696 + 654 WP_030069608.1 DsbA family oxidoreductase -
K1Y77_RS03370 (K1Y77_03365) 710916..712112 - 1197 WP_264430336.1 homoserine O-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10371.70 Da        Isoelectric Point: 8.8660

>T212303 WP_030069596.1 NZ_CP080627:707817-708080 [Halomonas qaidamensis]
MSSRLLSWTDESWSDYLYWQTQDKKTLKRINKLINDARRSPFEGIGKPEPLKENLAGFWSRRIDDTNRLVYAVDDNAITI
ISCRYHY

Download         Length: 264 bp

>T212303 NZ_CP107001:c4215162-4214989 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9480.68 Da        Isoelectric Point: 5.0733

>AT212303 WP_030069594.1 NZ_CP080627:707570-707824 [Halomonas qaidamensis]
MKIVSFTEARNSLKAVLDSVVNDADTAVITRRDSEDAVVMSLDYYNSLMETVHLLRSPANAEHLNRSIEQFKAGKVTHRD
LMDE

Download         Length: 255 bp

>AT212303 NZ_CP107001:c4215486-4215190 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S8YP06

Antitoxin

Source ID Structure
AlphaFold DB A0A7C9NMR2

References