Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 4195883..4196402 | Replicon | chromosome |
| Accession | NZ_CP080626 | ||
| Organism | Pseudomonas sp. S11A 273 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | - |
| Locus tag | K3F43_RS18700 | Protein ID | WP_101293397.1 |
| Coordinates | 4196112..4196402 (+) | Length | 97 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | - |
| Locus tag | K3F43_RS18695 | Protein ID | WP_045180850.1 |
| Coordinates | 4195883..4196122 (+) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K3F43_RS18660 (K3F43_18660) | 4191797..4191997 | - | 201 | WP_045180856.1 | hypothetical protein | - |
| K3F43_RS18665 (K3F43_18665) | 4192372..4192692 | + | 321 | WP_220639097.1 | DUF3077 domain-containing protein | - |
| K3F43_RS18670 (K3F43_18670) | 4192775..4192945 | + | 171 | Protein_3704 | type II toxin-antitoxin system RelB/DinJ family antitoxin | - |
| K3F43_RS18675 (K3F43_18675) | 4193070..4193564 | + | 495 | WP_101291788.1 | type VI secretion system tube protein Hcp | - |
| K3F43_RS18680 (K3F43_18680) | 4193576..4194421 | + | 846 | WP_101291787.1 | hypothetical protein | - |
| K3F43_RS18685 (K3F43_18685) | 4194432..4194803 | + | 372 | WP_101291786.1 | hypothetical protein | - |
| K3F43_RS18690 (K3F43_18690) | 4195339..4195659 | + | 321 | WP_045180853.1 | DUF3077 domain-containing protein | - |
| K3F43_RS18695 (K3F43_18695) | 4195883..4196122 | + | 240 | WP_045180850.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| K3F43_RS18700 (K3F43_18700) | 4196112..4196402 | + | 291 | WP_101293397.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| K3F43_RS18710 (K3F43_18710) | 4196698..4196940 | - | 243 | WP_101293396.1 | hypothetical protein | - |
| K3F43_RS18715 (K3F43_18715) | 4197409..4197768 | + | 360 | WP_101293395.1 | multidrug/spermidine efflux SMR transporter subunit MdtJ | - |
| K3F43_RS18720 (K3F43_18720) | 4197762..4198091 | + | 330 | WP_045180834.1 | multidrug/spermidine efflux SMR transporter subunit MdtI | - |
| K3F43_RS18725 (K3F43_18725) | 4198333..4199550 | - | 1218 | WP_045180831.1 | methyltransferase | - |
| K3F43_RS18730 (K3F43_18730) | 4199596..4200285 | - | 690 | WP_045180828.1 | ABC transporter permease | - |
| K3F43_RS18735 (K3F43_18735) | 4200282..4200938 | - | 657 | WP_045180825.1 | ABC transporter permease subunit | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 4192372..4203014 | 10642 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 97 a.a. Molecular weight: 11426.26 Da Isoelectric Point: 9.9160
>T212302 WP_101293397.1 NZ_CP080626:4196112-4196402 [Pseudomonas sp. S11A 273]
MTYSLEFDARALKEWHKLGDTVRQQFKKKLTAVLLNPRIEANRLHSLPDCYKIKLRSSGYRLVYQVIDQEIVVFVVAVDK
WEREQVYRKAAERLSE
MTYSLEFDARALKEWHKLGDTVRQQFKKKLTAVLLNPRIEANRLHSLPDCYKIKLRSSGYRLVYQVIDQEIVVFVVAVDK
WEREQVYRKAAERLSE
Download Length: 291 bp
>T212302 NZ_CP107001:c4119378-4119028 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACACGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACACGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA
Antitoxin
Download Length: 80 a.a. Molecular weight: 8995.43 Da Isoelectric Point: 5.1351
>AT212302 WP_045180850.1 NZ_CP080626:4195883-4196122 [Pseudomonas sp. S11A 273]
MASINVRIDDDLKARAYRELEKLGVTPSELMRQALQYVAERGQLPFKPVLMTEDDEALLAKVRERLAAPQRVKVSLDDL
MASINVRIDDDLKARAYRELEKLGVTPSELMRQALQYVAERGQLPFKPVLMTEDDEALLAKVRERLAAPQRVKVSLDDL
Download Length: 240 bp
>AT212302 NZ_CP107001:c4119623-4119372 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|