Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 2944658..2945241 Replicon chromosome
Accession NZ_CP080624
Organism Acidiferrobacter thiooxydans strain ZJ

Toxin (Protein)


Gene name vapC Uniprot ID A0A1C2G4F6
Locus tag A9R16_RS13820 Protein ID WP_065968798.1
Coordinates 2944658..2945038 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1C2G4H5
Locus tag A9R16_RS13825 Protein ID WP_065968799.1
Coordinates 2945035..2945241 (-) Length 69 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A9R16_RS13800 (A9R16_013960) 2940794..2942539 - 1746 WP_065972275.1 IS1634 family transposase -
A9R16_RS13805 (A9R16_013965) 2942696..2943205 + 510 WP_065968797.1 hypothetical protein -
A9R16_RS13810 (A9R16_013970) 2943220..2944326 + 1107 WP_211306971.1 tellurite resistance/C4-dicarboxylate transporter family protein -
A9R16_RS13815 (A9R16_013975) 2944387..2944530 + 144 WP_170132546.1 hypothetical protein -
A9R16_RS13820 (A9R16_013980) 2944658..2945038 - 381 WP_065968798.1 PIN domain-containing protein Toxin
A9R16_RS13825 (A9R16_013985) 2945035..2945241 - 207 WP_065968799.1 antitoxin of toxin-antitoxin stability system Antitoxin
A9R16_RS13830 (A9R16_013990) 2945929..2946336 - 408 WP_065968801.1 hypothetical protein -
A9R16_RS13835 (A9R16_013995) 2946333..2948651 - 2319 WP_065968802.1 cbb3-type cytochrome c oxidase subunit I -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13971.27 Da        Isoelectric Point: 5.1293

>T212299 WP_065968798.1 NZ_CP080624:c2945038-2944658 [Acidiferrobacter thiooxydans]
MSVLVDTSVWVDHFRNRNDVLVRLIEADMALTHPMVVAELACGTPPAPRTQTLGDIDLLRPCNQASLAEVRDFIEREKLY
GLGCGLVDIALLTSALLTSGASLWTLDKRLMGLAERFEVVYRPLPH

Download         Length: 381 bp

>T212299 NZ_CP107001:c3753913-3753515 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCCTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGAGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGGGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 69 a.a.        Molecular weight: 7565.66 Da        Isoelectric Point: 6.2807

>AT212299 WP_065968799.1 NZ_CP080624:c2945241-2945035 [Acidiferrobacter thiooxydans]
MRTTVTIDDAIYQKALEMADPNMDRADIFREAMKTYVRVQAAKRLAALGGAAPDMQDVPRRREEPAAG

Download         Length: 207 bp

>AT212299 NZ_CP107001:c3754209-3753916 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1C2G4F6

Antitoxin

Source ID Structure
AlphaFold DB A0A1C2G4H5

References