Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 1707100..1707790 Replicon chromosome
Accession NZ_CP080624
Organism Acidiferrobacter thiooxydans strain ZJ

Toxin (Protein)


Gene name tad Uniprot ID A0A1C2G1U1
Locus tag A9R16_RS08145 Protein ID WP_065970461.1
Coordinates 1707413..1707790 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID A0A1C2G1H5
Locus tag A9R16_RS08140 Protein ID WP_065970463.1
Coordinates 1707100..1707432 (-) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A9R16_RS08120 (A9R16_008200) 1702249..1702677 - 429 WP_083996330.1 hypothetical protein -
A9R16_RS08125 (A9R16_008205) 1702820..1703422 + 603 WP_065972265.1 hypothetical protein -
A9R16_RS08130 (A9R16_008210) 1703439..1706207 - 2769 WP_228579592.1 DotA/TraY family protein -
A9R16_RS08135 (A9R16_008215) 1706326..1707063 + 738 WP_083995829.1 SLOG family protein -
A9R16_RS08140 (A9R16_008220) 1707100..1707432 - 333 WP_065970463.1 helix-turn-helix transcriptional regulator Antitoxin
A9R16_RS08145 (A9R16_008225) 1707413..1707790 - 378 WP_065970461.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A9R16_RS08150 (A9R16_008230) 1708224..1708466 + 243 WP_141689280.1 hypothetical protein -
A9R16_RS08155 (A9R16_008235) 1708473..1709324 - 852 WP_218060436.1 site-specific integrase -
A9R16_RS08165 (A9R16_008245) 1710350..1712203 + 1854 WP_065970453.1 ABC-F family ATP-binding cassette domain-containing protein -
A9R16_RS08170 (A9R16_008250) 1712195..1712623 - 429 WP_065970447.1 molybdenum cofactor biosynthesis protein MoaE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1620295..1709453 89158


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-109)

Antitoxin

HigA2-like, helix-turn-helix domain

(18-97)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13830.95 Da        Isoelectric Point: 10.0402

>T212298 WP_065970461.1 NZ_CP080624:c1707790-1707413 [Acidiferrobacter thiooxydans]
MAGKEKPLFWIGSSKKDLVGLPVGVRKFFGHALDFAQRGDRHDAAKVLKGFGGAGVLEVVEDDADGTYRAVYTVRFEEAV
FVLHCFQKKSKSGIATPKEDMNIIRDRLKIAEAFAKELRHGKTGH

Download         Length: 378 bp

>T212298 NZ_CP107001:3743321-3743662 [Escherichia coli]
ATGAAAACTTTACCTGCAATAACTCAGCGGGCGGTGAAGCCCTGCCTGTCACCCGTGGCTGTCTGGCAAATGTTACTGAC
ACGTCTGCTGGAACAGCACTATGGTCTGACAATAAACGACACGCCATTCTGCAATGAGGCTGTGATTAAGGAACACATCG
ATGCCGGTATCACCCTAGCCGATGCCGTGAATTTTCTGGTAGAAAAATACGAGCTGGTTCGTATCGACAGGAAGGGATTT
AGCTGGCAGGAACAATCTCCTTATCTCCGGGCTGCAGACATTCTGCGAGCGCGGCAGGCAACTGGCTTGTTGCGGCAAAG
CCGTAACAACGTAGTACGATGA

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 11983.09 Da        Isoelectric Point: 10.6009

>AT212298 WP_065970463.1 NZ_CP080624:c1707432-1707100 [Acidiferrobacter thiooxydans]
MAKRVIEGIEVEAGSGNVFADLGLRDADKLKIKSGLVIEITRAVRRLGLTQEEAGRRMGIAQPRVSALLRGDFANLSERK
LMECLNRLGYDIEIKVKRAGGAVGHLKIAL

Download         Length: 333 bp

>AT212298 NZ_CP107001:3742983-3743300 [Escherichia coli]
ATGAGCAACCCTACCAGGGGCCTGCAGCGGGAGATTACACTGCGCCTGGGAGCCCGTCTGGTGCAGGAAGGCAACCGACT
GCATTATCTGGCTGACCGGGCCAGCATCACCGGCAAGTTCAGTGACATCGAATGCCGGAAGCTGGATGAAACATTCCCGC
ACTTTATCCTCCAGATGGAATCGATGCTGACCACCGGTGAACTCAGCCCCCACCATGCCCACTGCGTTACCCTGTACCAC
AACGATTTAACCTGCGAAGCCGACACCCTTGGCAGTTGCGGCTACGTATACATCGCCATTTACCCCACTCAGCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1C2G1U1

Antitoxin

Source ID Structure
AlphaFold DB A0A1C2G1H5

References