Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 4365372..4365898 | Replicon | chromosome |
| Accession | NZ_CP080620 | ||
| Organism | Escherichia coli strain TOP10 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | K3F56_RS21000 | Protein ID | WP_000323025.1 |
| Coordinates | 4365611..4365898 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | K3F56_RS20995 | Protein ID | WP_000534858.1 |
| Coordinates | 4365372..4365611 (+) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K3F56_RS20940 (4360399) | 4360399..4361166 | - | 768 | Protein_4123 | exonuclease | - |
| K3F56_RS20945 (4361259) | 4361259..4361450 | - | 192 | WP_001083297.1 | lysis protein YdfD | - |
| K3F56_RS20950 (4361447) | 4361447..4361635 | - | 189 | WP_000854559.1 | cell division inhibition protein DicB | - |
| K3F56_RS20955 (4362203) | 4362203..4362421 | - | 219 | WP_001171942.1 | protein YdfC | - |
| K3F56_RS22170 (4362451) | 4362451..4362579 | - | 129 | WP_000344964.1 | protein YdfB | - |
| K3F56_RS20960 (4362581) | 4362581..4362736 | - | 156 | WP_000379575.1 | DUF1391 family protein | - |
| K3F56_RS20965 (4362903) | 4362903..4363310 | - | 408 | WP_000448564.1 | DNA-binding transcriptional dual regulator DicA | - |
| K3F56_RS20970 (4363394) | 4363394..4363624 | + | 231 | WP_000920568.1 | dicB transcriptional regulator DicC | - |
| K3F56_RS20975 (4363608) | 4363608..4363886 | + | 279 | Protein_4131 | hypothetical protein | - |
| K3F56_RS20980 (4363921) | 4363921..4364070 | + | 150 | WP_011443592.1 | protein YdfW | - |
| K3F56_RS20985 (4364507) | 4364507..4364839 | - | 333 | WP_001301033.1 | FlxA-like family protein | - |
| K3F56_RS20990 (4365042) | 4365042..4365347 | - | 306 | WP_001326990.1 | protein YdfV | - |
| K3F56_RS20995 (4365372) | 4365372..4365611 | + | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| K3F56_RS21000 (4365611) | 4365611..4365898 | + | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| K3F56_RS21005 (4365970) | 4365970..4366125 | + | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| K3F56_RS21010 (4366342) | 4366342..4366593 | + | 252 | WP_000980994.1 | protein Rem | - |
| K3F56_RS21015 (4366660) | 4366660..4366938 | + | 279 | WP_012304870.1 | hypothetical protein | - |
| K3F56_RS21020 (4366940) | 4366940..4367989 | + | 1050 | WP_001265198.1 | DUF968 domain-containing protein | - |
| K3F56_RS21025 (4368003) | 4368003..4368755 | + | 753 | WP_001047135.1 | antitermination protein | - |
| K3F56_RS21030 (4369033) | 4369033..4369122 | - | 90 | WP_120795389.1 | hypothetical protein | - |
| K3F56_RS21035 (4369177) | 4369177..4369389 | - | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| K3F56_RS21040 (4369690) | 4369690..4369905 | + | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
| K3F56_RS21045 (4370269) | 4370269..4370439 | - | 171 | WP_211180497.1 | putative zinc-binding protein YnfU | - |
| K3F56_RS21050 (4370659) | 4370659..4370874 | + | 216 | WP_000839590.1 | phage lysis protein EssD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 4361447..4374197 | 12750 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T212294 WP_000323025.1 NZ_CP080620:4365611-4365898 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T212294 NZ_CP107001:c2382413-2382237 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT212294 WP_000534858.1 NZ_CP080620:4365372-4365611 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT212294 NZ_CP107001:c2382191-2381775 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|