Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | rnlAB/RnlA-RnlB |
Location | 2653285..2654722 | Replicon | chromosome |
Accession | NZ_CP080620 | ||
Organism | Escherichia coli strain TOP10 |
Toxin (Protein)
Gene name | rnlA | Uniprot ID | P52129 |
Locus tag | K3F56_RS12615 | Protein ID | WP_000155570.1 |
Coordinates | 2653285..2654358 (+) | Length | 358 a.a. |
Antitoxin (Protein)
Gene name | rnlB | Uniprot ID | P52130 |
Locus tag | K3F56_RS12620 | Protein ID | WP_000461704.1 |
Coordinates | 2654351..2654722 (+) | Length | 124 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
K3F56_RS12600 (2648718) | 2648718..2650907 | - | 2190 | WP_000136402.1 | DEAD/DEAH box helicase | - |
K3F56_RS12605 (2650904) | 2650904..2652520 | - | 1617 | WP_000445380.1 | anti-bacteriophage protein AbpA | - |
K3F56_RS12610 (2652880) | 2652880..2653143 | - | 264 | WP_000502050.1 | DUF1524 domain-containing protein | - |
K3F56_RS12615 (2653285) | 2653285..2654358 | + | 1074 | WP_000155570.1 | type II toxin-antitoxin system toxin mRNA endoribonuclease RnlA | Toxin |
K3F56_RS12620 (2654351) | 2654351..2654722 | + | 372 | WP_000461704.1 | type II toxin-antitoxin system antitoxin RnlB | Antitoxin |
K3F56_RS12625 (2655077) | 2655077..2655940 | + | 864 | WP_000787597.1 | GTPase family protein | - |
K3F56_RS12630 (2656032) | 2656032..2656853 | + | 822 | WP_000197391.1 | DUF932 domain-containing protein | - |
K3F56_RS12635 (2657070) | 2657070..2657771 | + | 702 | WP_000189409.1 | WYL domain-containing protein | - |
K3F56_RS12640 (2657812) | 2657812..2658048 | + | 237 | WP_001144029.1 | protein YpjK | - |
K3F56_RS12645 (2658048) | 2658048..2658491 | + | 444 | WP_000824222.1 | lipoprotein YfjS | - |
K3F56_RS12650 (2658515) | 2658515..2658982 | + | 468 | WP_000702495.1 | protein YfjT | - |
K3F56_RS22105 (2659369) | 2659369..2659521 | - | 153 | Protein_2491 | arsenate reductase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 358 a.a. Molecular weight: 40061.13 Da Isoelectric Point: 6.8293
>T212272 WP_000155570.1 NZ_CP080620:2653285-2654358 [Escherichia coli]
MTIRSYKNLNLVRANIETESRQFIENKNYSIQSIGPMPGSRAGLRVVFTRPGVNLATVDIFYNGDGSTTIQYLTGANRSL
GQELADHLFETINPAEFEQVNMVLQGFVETSVLPVLELSADESHIEFREHSRNAHTVVWKIISTSYQDELTVSLHITTGK
LQIQGRPLSCYRVFTFNLAALLDLQGLEKVLIRQEDGKANIVQQEVARTYLQTVMADAYPHLHVTAEKLLVSGLCVKLAA
PDLPDYCMLLYPELRTIEGVLKSKMSGLGMPVQQPAGFGTYFDKPAAHYILKPQFAATLRPEQINIISTAYTFFNVERHS
LFHMETVVDASRMISDMARLMGKATRAWGIIKDLYIV
MTIRSYKNLNLVRANIETESRQFIENKNYSIQSIGPMPGSRAGLRVVFTRPGVNLATVDIFYNGDGSTTIQYLTGANRSL
GQELADHLFETINPAEFEQVNMVLQGFVETSVLPVLELSADESHIEFREHSRNAHTVVWKIISTSYQDELTVSLHITTGK
LQIQGRPLSCYRVFTFNLAALLDLQGLEKVLIRQEDGKANIVQQEVARTYLQTVMADAYPHLHVTAEKLLVSGLCVKLAA
PDLPDYCMLLYPELRTIEGVLKSKMSGLGMPVQQPAGFGTYFDKPAAHYILKPQFAATLRPEQINIISTAYTFFNVERHS
LFHMETVVDASRMISDMARLMGKATRAWGIIKDLYIV
Download Length: 1074 bp
>T212272 NZ_CP107000:2671044-2671151 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA
Antitoxin
Download Length: 124 a.a. Molecular weight: 13664.69 Da Isoelectric Point: 4.2391
>AT212272 WP_000461704.1 NZ_CP080620:2654351-2654722 [Escherichia coli]
MFEITGINVSGALKAVVMATGFENPLSSVNEIETKLSALLGSETTGEILFDLLCANGPEWNRFVTLEMKYGRIMLDTAKI
IDEQDVPTHILSKLTFTLRNHPEYLEASVLSPDDVRQVLSMDF
MFEITGINVSGALKAVVMATGFENPLSSVNEIETKLSALLGSETTGEILFDLLCANGPEWNRFVTLEMKYGRIMLDTAKI
IDEQDVPTHILSKLTFTLRNHPEYLEASVLSPDDVRQVLSMDF
Download Length: 372 bp
>AT212272 NZ_CP107000:c2670997-2670931 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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