Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 1754587..1755107 Replicon chromosome
Accession NZ_CP080599
Organism Nocardiopsis sp. MT53

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag K1J57_RS07565 Protein ID WP_220563741.1
Coordinates 1754587..1754844 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag K1J57_RS07570 Protein ID WP_220563742.1
Coordinates 1754841..1755107 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K1J57_RS07540 (K1J57_07540) 1750403..1751230 + 828 WP_255647132.1 ABC transporter permease -
K1J57_RS07545 (K1J57_07545) 1751227..1752348 + 1122 WP_220563737.1 ABC transporter substrate-binding protein -
K1J57_RS07550 (K1J57_07550) 1752448..1753536 + 1089 WP_220563738.1 LLM class flavin-dependent oxidoreductase -
K1J57_RS07555 (K1J57_07555) 1753533..1754201 + 669 WP_220563739.1 isochorismatase family cysteine hydrolase -
K1J57_RS07560 (K1J57_07560) 1754270..1754521 + 252 WP_220563740.1 DUF2795 domain-containing protein -
K1J57_RS07565 (K1J57_07565) 1754587..1754844 - 258 WP_220563741.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K1J57_RS07570 (K1J57_07570) 1754841..1755107 - 267 WP_220563742.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
K1J57_RS07575 (K1J57_07575) 1755210..1756124 + 915 WP_220563743.1 aminoglycoside phosphotransferase family protein -
K1J57_RS07580 (K1J57_07580) 1756117..1757622 + 1506 WP_220563744.1 helix-turn-helix domain-containing protein -
K1J57_RS07585 (K1J57_07585) 1757833..1759146 + 1314 WP_220563745.1 MFS transporter -
K1J57_RS07590 (K1J57_07590) 1759213..1760103 - 891 WP_220563746.1 alpha/beta hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-82)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(8-66)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9853.38 Da        Isoelectric Point: 9.9729

>T212265 WP_220563741.1 NZ_CP080599:c1754844-1754587 [Nocardiopsis sp. MT53]
VTYRTIFRPEAREELRKLPRTVAMSVFRKLTELEADPLGFGTTALVGSPEVRRLRVGDYRVIYTVEHDRLIVWVVHVGHR
SGVYD

Download         Length: 258 bp

>T212265 NZ_CP107000:1800483-1800737 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10220.67 Da        Isoelectric Point: 4.4909

>AT212265 WP_220563742.1 NZ_CP080599:c1755107-1754841 [Nocardiopsis sp. MT53]
MNEVQVETIRQVRDHIADVVDRADRDDSPTVITRRGREVAAVVPIEMLRRYQRLEEQEILRLVRERMADPSPGIPMEQVM
AEILEGPE

Download         Length: 267 bp

>AT212265 NZ_CP107000:1800235-1800486 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References