Detailed information of TA system TA212264

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 6089099..6089549
• Replicon: chromosome
• Accession: NZ_CP080597
• Organism: Pseudomonas sp. ERGC3:05

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: K2E96_RS28490
• Protein ID: WP_082895828.1
• Coordinates: 6089099..6089371 (-)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A172YWJ3
• Locus tag: K2E96_RS28495
• Protein ID: WP_064450837.1
• Coordinates: 6089361..6089549 (-)
• Length: 63 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K2E96_RS28470 (K2E96_28065)	6085106..6086482	+	1377	WP_064450841.1	L-serine ammonia-lyase	-
K2E96_RS28475 (K2E96_28070)	6086545..6087831	+	1287	WP_221294007.1	serine/threonine transporter	-
K2E96_RS28480 (K2E96_28075)	6088131..6088448	+	318	WP_053254548.1	DUF3509 domain-containing protein	-
K2E96_RS28485 (K2E96_28080)	6088445..6088933	-	489	WP_064450838.1	phosphate-starvation-inducible PsiE family protein	-
K2E96_RS28490 (K2E96_28085)	6089099..6089371	-	273	WP_082895828.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
K2E96_RS28495 (K2E96_28090)	6089361..6089549	-	189	WP_064450837.1	hypothetical protein	Antitoxin
K2E96_RS28500 (K2E96_28095)	6089702..6089905	-	204	Protein_5617	DUF6124 family protein	-
K2E96_RS28505 (K2E96_28100)	6090235..6090495	+	261	WP_016974596.1	YebG family protein	-
K2E96_RS28510 (K2E96_28105)	6090551..6091570	-	1020	WP_064450835.1	Glu/Leu/Phe/Val dehydrogenase dimerization domain-containing protein	-
K2E96_RS28515 (K2E96_28110)	6091758..6092562	+	805	Protein_5620	hypothetical protein	-
K2E96_RS28520 (K2E96_28115)	6092617..6093987	-	1371	WP_259762986.1	aromatic acid/H+ symport family MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-88)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10279.93 Da
• Isoelectric Point: 9.9280

>T212264 WP_082895828.1 NZ_CP080597:c6089371-6089099 [Pseudomonas sp. ERGC3:05]
MLVEWAPAARAQLRQITDYISDRNPVAALELNQAIEACVLALSRRPHLYRPGRVVGTREMVVHPNYLVVYQVTDSIRVLS
VLHARQRYPS

Nucleotide

• Length: 273 bp

>T212264 NZ_CP107000:1800235-1800486 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Antitoxin

Protein

• Length: 63 a.a.
• Molecular weight: 6856.54 Da
• Isoelectric Point: 4.3558

>AT212264 WP_064450837.1 NZ_CP080597:c6089549-6089361 [Pseudomonas sp. ERGC3:05]
MDTSFSSGIPTDTEAQADSYDRWFRAKVQAALDDPSPGIPHDEVMAEMRELIESKRKKGDAG

Nucleotide

• Length: 189 bp

>AT212264 NZ_CP107000:1800483-1800737 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Structures

Antitoxin

• AlphaFold DB: A0A172YWJ3