212261

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA(toxin)
Location 3690283..3690896 Replicon chromosome
Accession NZ_CP080597
Organism Pseudomonas sp. ERGC3:05

Toxin (Protein)


Gene name hicA Uniprot ID A0A172Z267
Locus tag K2E96_RS17360 Protein ID WP_053256594.1
Coordinates 3690645..3690896 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A172Z377
Locus tag K2E96_RS17355 Protein ID WP_064452746.1
Coordinates 3690283..3690648 (-) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K2E96_RS17330 (K2E96_17100) 3685414..3686370 + 957 WP_221294971.1 AAA family ATPase -
K2E96_RS17335 (K2E96_17105) 3686438..3687010 + 573 WP_221294970.1 DUF2239 family protein -
K2E96_RS17340 (K2E96_17110) 3687036..3688391 + 1356 WP_221294969.1 MATE family efflux transporter -
K2E96_RS17345 (K2E96_17115) 3688375..3688968 - 594 WP_221294968.1 TetR/AcrR family transcriptional regulator -
K2E96_RS17350 (K2E96_17120) 3689111..3690300 + 1190 Protein_3406 MFS transporter -
K2E96_RS17355 (K2E96_17125) 3690283..3690648 - 366 WP_064452746.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
K2E96_RS17360 (K2E96_17130) 3690645..3690896 - 252 WP_053256594.1 type II toxin-antitoxin system HicA family toxin Toxin

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-76)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9485.04 Da        Isoelectric Point: 9.6594

>T212261 WP_053256594.1 NZ_CP080597:c3690896-3690645 [Pseudomonas sp. ERGC3:05]
VSKNEKLLAKLLNEHMAFTWPELVTLLHRLGYTQIEGAGSRVKFDIGDPSAMISLHKPHPGNELKHYIRRQIIEQLKSGE
LIQ

Download         Length: 252 bp

>T212261 NZ_CP107000:977325-977660 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13269.22 Da        Isoelectric Point: 6.9476

>AT212261 WP_064452746.1 NZ_CP080597:c3690648-3690283 [Pseudomonas sp. ERGC3:05]
VNNQLKYKGYIGSIEASLEDNCLFGKILFIKALVSYEGKTVAELDAAFREAVDDYLATCHALGQTPEKPCKGSFNVRVGH
DLHLAAALAATRKKVTLNDLTRQALNEFLQHHCTEPLPVLG

Download         Length: 366 bp

>AT212261 NZ_CP107000:977077-977325 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A172Z267

Antitoxin

Source ID Structure
AlphaFold DB A0A172Z377

References