Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | phd-doc/Doc-Phd |
| Location | 39294..39895 | Replicon | plasmid pCrono684-2 |
| Accession | NZ_CP080596 | ||
| Organism | Cronobacter sakazakii strain Crono-684 | ||
Toxin (Protein)
| Gene name | doc | Uniprot ID | - |
| Locus tag | K2Y34_RS21465 | Protein ID | WP_033551393.1 |
| Coordinates | 39294..39674 (-) | Length | 127 a.a. |
Antitoxin (Protein)
| Gene name | phd | Uniprot ID | U9YQH9 |
| Locus tag | K2Y34_RS21470 | Protein ID | WP_001190712.1 |
| Coordinates | 39674..39895 (-) | Length | 74 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K2Y34_RS21425 (K2Y34_21375) | 34686..34895 | + | 210 | WP_000874156.1 | hypothetical protein | - |
| K2Y34_RS21430 (K2Y34_21380) | 35006..35857 | + | 852 | WP_000611664.1 | phage repressor protein C1 | - |
| K2Y34_RS21435 (K2Y34_21385) | 35890..37005 | - | 1116 | WP_033551397.1 | phage antirepressor KilAC domain-containing protein | - |
| K2Y34_RS21440 | 37002..37223 | - | 222 | WP_072019028.1 | host cell division inhibitor Icd-like protein | - |
| K2Y34_RS21445 | 37242..37361 | - | 120 | WP_001376634.1 | ash family protein | - |
| K2Y34_RS21450 (K2Y34_21395) | 37583..37915 | - | 333 | WP_033551395.1 | hypothetical protein | - |
| K2Y34_RS21455 (K2Y34_21400) | 38039..39082 | - | 1044 | WP_033551394.1 | DUF968 domain-containing protein | - |
| K2Y34_RS21460 | 39110..39289 | - | 180 | WP_000113018.1 | hypothetical protein | - |
| K2Y34_RS21465 (K2Y34_21405) | 39294..39674 | - | 381 | WP_033551393.1 | type II toxin-antitoxin system death-on-curing family toxin | Toxin |
| K2Y34_RS21470 (K2Y34_21410) | 39674..39895 | - | 222 | WP_001190712.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| K2Y34_RS21475 (K2Y34_21415) | 40078..40254 | + | 177 | Protein_50 | type I restriction-modification system subunit M N-terminal domain-containing protein | - |
| K2Y34_RS21480 (K2Y34_21420) | 40312..40718 | + | 407 | Protein_51 | IS1 family transposase | - |
| K2Y34_RS21485 (K2Y34_21425) | 40752..42503 | - | 1752 | Protein_52 | Tn3-like element TnAs1 family transposase | - |
| K2Y34_RS21490 (K2Y34_21430) | 42507..42899 | + | 393 | WP_001351729.1 | isochorismatase family cysteine hydrolase | - |
| K2Y34_RS21495 (K2Y34_21435) | 43037..43921 | + | 885 | WP_000058717.1 | EamA family transporter | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | tet(A) / qnrS1 / dfrA14 / blaTEM-1C / floR | - | 1..94206 | 94206 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 127 a.a. Molecular weight: 13559.26 Da Isoelectric Point: 5.6277
>T212260 WP_033551393.1 NZ_CP080596:c39674-39294 [Cronobacter sakazakii]
MRHISPEELIALHDANINRYGGLPGMSDPGRAEAIIGRVQARVAYEEITDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVFDSPELADLTVGAATGGISVSSVADTLRRLYGSSE
MRHISPEELIALHDANINRYGGLPGMSDPGRAEAIIGRVQARVAYEEITDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVFDSPELADLTVGAATGGISVSSVADTLRRLYGSSE
Download Length: 381 bp
>T212260 NZ_CP107000:846265-846672 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA
Antitoxin
Download Length: 74 a.a. Molecular weight: 8133.10 Da Isoelectric Point: 4.7708
>AT212260 WP_001190712.1 NZ_CP080596:c39895-39674 [Cronobacter sakazakii]
MQSINFRTARGNLSEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDTLDSTNKELVNR
MQSINFRTARGNLSEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDTLDSTNKELVNR
Download Length: 222 bp
>AT212260 NZ_CP107000:846018-846284 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|