21226

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 823106..823620 Replicon chromosome
Accession NC_007350
Organism Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305

Toxin (Protein)


Gene name TsdT Uniprot ID Q49Z34
Locus tag SSP_RS03940 Protein ID WP_011302693.1
Coordinates 823414..823620 (+) Length 69 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q49Z35
Locus tag SSP_RS03935 Protein ID WP_002482740.1
Coordinates 823106..823399 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SSP_RS03910 818268..819059 + 792 WP_011302688.1 hydroxyethylthiazole kinase -
SSP_RS03915 819059..819697 + 639 WP_011302689.1 thiamine phosphate synthase -
SSP_RS03920 819785..820654 + 870 WP_011302690.1 membrane protein insertase YidC -
SSP_RS03925 820736..821410 - 675 WP_170178158.1 HD domain-containing protein -
SSP_RS03930 821479..822963 - 1485 WP_011302692.1 cardiolipin synthase -
SSP_RS03935 823106..823399 + 294 WP_002482740.1 copper-sensing transcriptional repressor CsoR Antitoxin
SSP_RS03940 823414..823620 + 207 WP_011302693.1 hypothetical protein Toxin
SSP_RS12950 823833..823973 + 141 WP_002482742.1 hypothetical protein -
SSP_RS03945 824266..825471 - 1206 WP_011302694.1 rod shape-determining protein RodA -
SSP_RS03950 825720..826790 + 1071 WP_011302695.1 D-alanine--D-alanine ligase -
SSP_RS03955 826803..828158 + 1356 WP_011302696.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 69 a.a.        Molecular weight: 8040.28 Da        Isoelectric Point: 4.3776

>T21226 WP_011302693.1 NC_007350:823414-823620 [Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 = NCTC]
MQSKVIYIAELYNEKQKLQIEERLMKLYGVFKVSTDIEEGAIFVDFETPANLNNLEKEVYDLGYKIIY

Download         Length: 207 bp

>T21226 NC_007350:823414-823620 [Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 = NCTC]
ATGCAATCAAAAGTTATTTATATTGCTGAACTTTATAATGAGAAGCAAAAATTACAAATTGAAGAAAGACTAATGAAACT
TTATGGTGTGTTTAAAGTTAGTACAGATATAGAAGAAGGCGCAATCTTTGTAGATTTTGAAACGCCTGCAAATTTGAATA
ATTTAGAAAAAGAAGTGTACGATTTAGGTTATAAAATAATTTATTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11221.90 Da        Isoelectric Point: 6.3282

>AT21226 WP_002482740.1 NC_007350:823106-823399 [Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 = NCTC]
MTEIQKAHHSEEIKANLKSRLNRIEGQVKAINRMVEEDVYCDDVLTQIRATRSALNSVATKLLDHHMKSCIMDKVEQGHE
QEAMEELLVTFQKLMKD

Download         Length: 294 bp

>AT21226 NC_007350:823106-823399 [Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 = NCTC]
ATGACTGAAATACAAAAAGCGCATCATTCAGAAGAAATAAAAGCAAATTTAAAATCAAGACTTAATAGAATCGAAGGTCA
AGTTAAAGCCATAAATCGTATGGTAGAGGAAGATGTGTACTGTGACGATGTGCTTACACAAATAAGAGCTACGCGATCCG
CATTAAATAGTGTCGCTACTAAATTATTAGATCATCATATGAAAAGTTGTATTATGGATAAAGTTGAACAGGGTCATGAA
CAAGAAGCGATGGAAGAACTACTTGTAACTTTTCAAAAATTGATGAAGGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q49Z34

Antitoxin

Source ID Structure
AlphaFold DB A0A380HKS9

References