Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 102711..104314 Replicon plasmid pCrono684-1
Accession NZ_CP080595
Organism Cronobacter sakazakii strain Crono-684

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag K2Y34_RS21165 Protein ID WP_015387275.1
Coordinates 102711..104030 (-) Length 440 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag K2Y34_RS21170 Protein ID WP_007854617.1
Coordinates 104033..104314 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K2Y34_RS21155 (K2Y34_21100) 98093..100624 - 2532 WP_015387273.1 malto-oligosyltrehalose synthase -
K2Y34_RS21160 (K2Y34_21105) 100621..102405 - 1785 WP_015387274.1 malto-oligosyltrehalose trehalohydrolase -
K2Y34_RS21165 (K2Y34_21110) 102711..104030 - 1320 WP_015387275.1 type II toxin-antitoxin system HipA family toxin Toxin
K2Y34_RS21170 (K2Y34_21115) 104033..104314 - 282 WP_007854617.1 helix-turn-helix domain-containing protein Antitoxin
K2Y34_RS21175 (K2Y34_21120) 104445..105329 - 885 WP_015387276.1 siderophore-interacting protein -
K2Y34_RS21180 (K2Y34_21125) 105326..106537 - 1212 WP_015387277.1 MFS transporter -
K2Y34_RS21185 (K2Y34_21130) 106673..108421 + 1749 WP_029463996.1 IucA/IucC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - pla / vipA/tssB / vipB/tssC / mgtB / iucA / iucB / iucC / iutA 1..118144 118144


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(7-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(21-69)


Sequences

Toxin        


Download         Length: 440 a.a.        Molecular weight: 49009.97 Da        Isoelectric Point: 6.8730

>T212259 WP_015387275.1 NZ_CP080595:c104030-102711 [Cronobacter sakazakii]
MRRTSRLALWMNGLPVGYWDKHNGEDRLTYLPEWIADPQGRPLSLSLPFTPGNQSYRGAQVRDYFDNLLPDSENIRRRLA
MRYRAQSLEPFDLLAELGRDCVGAIQLLPAGEAPEGLFTIRARPLSTVDIAAMLRHTAEAFPGQHGGEEELRLSIAGAQE
KTALLWHEGQWCLPEGNTPTTHIFKLPLGLVGNMQADMRTSIENEWLCAQLLAAWDIPVAHTQMAQFEEQKVLIVERFDR
RLSADGQWWLRLPQEDMCQALGVSPLRKYQADGGPGIGDIMTILSRSENAQADRANFFRAQIIFWILAATDGHAKNFSIA
HLPGNRYHLTPLYDVLSAWPVIGPGNNQIAWQKCKLAMAVRGGSNYYHLSQIRRRHWLRQGELAGLSAAQVNDMIDALTA
SAPAVFARVADALPVDFPASLADVIFNGMRQQCARLAAA

Download         Length: 1320 bp

>T212259 NZ_CP107000:714669-714965 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10474.98 Da        Isoelectric Point: 7.8283

>AT212259 WP_007854617.1 NZ_CP080595:c104314-104033 [Cronobacter sakazakii]
MNTRYPLKTLSQLRPLLVGFRKKQGLTQKEVSARLGVTQQTYARLEANPETASIERLFRVFNVLGIEMTLCETQAAEPDA
PACDDSPAHREAW

Download         Length: 282 bp

>AT212259 NZ_CP107000:714967-715362 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References