Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 3911719..3912304 Replicon chromosome
Accession NZ_CP080594
Organism Cronobacter sakazakii strain Crono-684

Toxin (Protein)


Gene name PumA Uniprot ID A0A853H7C5
Locus tag K2Y34_RS18495 Protein ID WP_014727945.1
Coordinates 3911719..3912024 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A2S9UB62
Locus tag K2Y34_RS18500 Protein ID WP_007852536.1
Coordinates 3912029..3912304 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K2Y34_RS18470 (K2Y34_18425) 3907753..3909345 + 1593 WP_004387519.1 RNA repair transcriptional activator RtcR -
K2Y34_RS18475 (K2Y34_18430) 3909507..3910442 + 936 WP_004387518.1 ketopantoate/pantoate/pantothenate transporter PanS -
K2Y34_RS18480 (K2Y34_18435) 3910533..3910805 + 273 WP_004387517.1 DUF3811 domain-containing protein -
K2Y34_RS18485 (K2Y34_18440) 3910832..3911155 - 324 WP_015386308.1 helix-turn-helix transcriptional regulator -
K2Y34_RS18490 (K2Y34_18445) 3911152..3911502 - 351 WP_007852532.1 type II toxin-antitoxin system RelE/ParE family toxin -
K2Y34_RS18495 (K2Y34_18450) 3911719..3912024 + 306 WP_014727945.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K2Y34_RS18500 (K2Y34_18455) 3912029..3912304 + 276 WP_007852536.1 putative addiction module antidote protein Antitoxin
K2Y34_RS18505 (K2Y34_18460) 3912321..3913952 - 1632 WP_007852537.1 Na/Pi cotransporter family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-93)

Antitoxin

Uncharacterized protein HI1420

(3-89)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11588.58 Da        Isoelectric Point: 10.3395

>T212258 WP_014727945.1 NZ_CP080594:3911719-3912024 [Cronobacter sakazakii]
MKHIFQTEVFRRWQASLKDQRVKTMIAARLFRLANGLPGDVKPVGAGISELRIHYGAGYRIYFKQHGEVIVILLCGGDKH
TQDKDILLAKMLADLPENQWR

Download         Length: 306 bp

>T212258 NZ_CP107000:648758-649072 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 9597.06 Da        Isoelectric Point: 6.4609

>AT212258 WP_007852536.1 NZ_CP080594:3912029-3912304 [Cronobacter sakazakii]
MKLTEYDPAAALVDDEEIAFFMADALETGDAGHIAKALGVVARAKGMSHIAAQTGLSREQLYRSFSDKGNPTLKTTLAVM
KALGLGLTVKS

Download         Length: 276 bp

>AT212258 NZ_CP107000:649069-649485 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A853H7C5

Antitoxin

Source ID Structure
AlphaFold DB A0A2S9UB62

References