Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 3910832..3911502 Replicon chromosome
Accession NZ_CP080594
Organism Cronobacter sakazakii strain Crono-684

Toxin (Protein)


Gene name tad Uniprot ID -
Locus tag K2Y34_RS18490 Protein ID WP_007852532.1
Coordinates 3911152..3911502 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID -
Locus tag K2Y34_RS18485 Protein ID WP_015386308.1
Coordinates 3910832..3911155 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K2Y34_RS18465 (K2Y34_18420) 3906144..3907277 - 1134 WP_004387521.1 slipin family protein -
K2Y34_RS18470 (K2Y34_18425) 3907753..3909345 + 1593 WP_004387519.1 RNA repair transcriptional activator RtcR -
K2Y34_RS18475 (K2Y34_18430) 3909507..3910442 + 936 WP_004387518.1 ketopantoate/pantoate/pantothenate transporter PanS -
K2Y34_RS18480 (K2Y34_18435) 3910533..3910805 + 273 WP_004387517.1 DUF3811 domain-containing protein -
K2Y34_RS18485 (K2Y34_18440) 3910832..3911155 - 324 WP_015386308.1 helix-turn-helix transcriptional regulator Antitoxin
K2Y34_RS18490 (K2Y34_18445) 3911152..3911502 - 351 WP_007852532.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K2Y34_RS18495 (K2Y34_18450) 3911719..3912024 + 306 WP_014727945.1 type II toxin-antitoxin system RelE/ParE family toxin -
K2Y34_RS18500 (K2Y34_18455) 3912029..3912304 + 276 WP_007852536.1 putative addiction module antidote protein -
K2Y34_RS18505 (K2Y34_18460) 3912321..3913952 - 1632 WP_007852537.1 Na/Pi cotransporter family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-90)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12977.99 Da        Isoelectric Point: 10.2932

>T212257 WP_007852532.1 NZ_CP080594:c3911502-3911152 [Cronobacter sakazakii]
MIKPLFWVGQARKDLQALPEDVQDLFGYALYLAQQGRRHPQARPLKGFGGAGVLEVVEDYQGNAFRAVYTVRLGEAIYVL
HVFQKKSSSGIATPRPEMEKIEQRLKAAQRHAGGLK

Download         Length: 351 bp

>T212257 NZ_CP107000:c605876-605412 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 11804.88 Da        Isoelectric Point: 6.9798

>AT212257 WP_015386308.1 NZ_CP080594:c3911155-3910832 [Cronobacter sakazakii]
MTADIERSNGNVYDDLGLIDAEEMELKAQLAMAISDILKARGLTQQEAARLLGMTQPKLSLLLRGQFRGISETKMMACLM
LLGRDISIVVGEAQHARGKMRLIYQPA

Download         Length: 324 bp

>AT212257 NZ_CP107000:c606211-605876 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References