Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 3717844..3718363 Replicon chromosome
Accession NZ_CP080594
Organism Cronobacter sakazakii strain Crono-684

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag K2Y34_RS17555 Protein ID WP_004385271.1
Coordinates 3717844..3718131 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag K2Y34_RS17560 Protein ID WP_004385270.1
Coordinates 3718121..3718363 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K2Y34_RS17535 (K2Y34_17495) 3713041..3713571 - 531 WP_004386036.1 NAD(P)H-dependent oxidoreductase -
K2Y34_RS17540 (K2Y34_17500) 3713674..3714555 + 882 WP_007852197.1 LysR family transcriptional regulator -
K2Y34_RS17545 (K2Y34_17505) 3714852..3716987 + 2136 WP_015386331.1 anaerobic ribonucleoside-triphosphate reductase -
K2Y34_RS17550 (K2Y34_17510) 3717372..3717836 + 465 WP_004385272.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
K2Y34_RS17555 (K2Y34_17515) 3717844..3718131 - 288 WP_004385271.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K2Y34_RS17560 (K2Y34_17520) 3718121..3718363 - 243 WP_004385270.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
K2Y34_RS17565 (K2Y34_17525) 3718441..3720351 - 1911 WP_004385269.1 PRD domain-containing protein -
K2Y34_RS17570 (K2Y34_17530) 3720465..3721205 - 741 WP_004385268.1 KDGP aldolase family protein -
K2Y34_RS17575 (K2Y34_17535) 3721202..3722320 - 1119 WP_004385267.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10811.80 Da        Isoelectric Point: 10.5836

>T212256 WP_004385271.1 NZ_CP080594:c3718131-3717844 [Cronobacter sakazakii]
MSYKLVFDPRALKEWHKLGETVKAQFKKKLAHVLAAPRVKSARLSGLPDCYKIKLRTSGYRLVYQVRDDAVCVLVIAIGK
RENLTVYQGAGHRLE

Download         Length: 288 bp

>T212256 NZ_CP107000:183125-183232 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9037.45 Da        Isoelectric Point: 5.1088

>AT212256 WP_004385270.1 NZ_CP080594:c3718363-3718121 [Cronobacter sakazakii]
MATINVRLDDKLKNEAYAVLEKLGITPTEAVRLLFQYVAQNGRMPVKTLTVSDSEEALLRTVRERLADPRPGIRVDLDEL

Download         Length: 243 bp

>AT212256 NZ_CP107000:c183077-183011 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References