Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PanAT/DUF4065(antitoxin)
Location 3629244..3630340 Replicon chromosome
Accession NZ_CP080594
Organism Cronobacter sakazakii strain Crono-684

Toxin (Protein)


Gene name panT Uniprot ID -
Locus tag K2Y34_RS17095 Protein ID WP_260999558.1
Coordinates 3629244..3629828 (-) Length 195 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID -
Locus tag K2Y34_RS17100 Protein ID WP_260999559.1
Coordinates 3629870..3630340 (-) Length 157 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K2Y34_RS17075 (K2Y34_17035) 3625103..3625957 - 855 WP_260999556.1 GPO family capsid scaffolding protein -
K2Y34_RS17080 (K2Y34_17040) 3626124..3627893 + 1770 WP_007796312.1 terminase ATPase subunit family protein -
K2Y34_RS17085 (K2Y34_17045) 3627893..3628927 + 1035 WP_080865707.1 phage portal protein -
K2Y34_RS17090 (K2Y34_17050) 3629042..3629224 - 183 WP_260999557.1 hypothetical protein -
K2Y34_RS17095 (K2Y34_17055) 3629244..3629828 - 585 WP_260999558.1 hypothetical protein Toxin
K2Y34_RS17100 (K2Y34_17060) 3629870..3630340 - 471 WP_260999559.1 DUF4065 domain-containing protein Antitoxin
K2Y34_RS17105 (K2Y34_17065) 3630741..3630974 - 234 WP_105652359.1 DinI family protein -
K2Y34_RS17110 (K2Y34_17070) 3630986..3631177 - 192 WP_241701015.1 hypothetical protein -
K2Y34_RS17115 (K2Y34_17075) 3631344..3633593 - 2250 WP_260999560.1 replication endonuclease -
K2Y34_RS17120 (K2Y34_17080) 3633590..3634468 - 879 WP_260999561.1 DNA adenine methylase -
K2Y34_RS17125 (K2Y34_17085) 3634465..3634689 - 225 WP_085662153.1 TraR/DksA family transcriptional regulator -
K2Y34_RS17130 (K2Y34_17090) 3634689..3634922 - 234 WP_260999562.1 DUF2732 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3603216..3638093 34877


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin SocA-like, Panacea domain

(28-123)


Sequences

Toxin        


Download         Length: 195 a.a.        Molecular weight: 21707.51 Da        Isoelectric Point: 4.7081

>T212255 WP_260999558.1 NZ_CP080594:c3629828-3629244 [Cronobacter sakazakii]
MSIDNDLFESILRGAISANIDDLVKTLTSTEPQNSSTPPPQEEIDGADDKAQKEAQAFDTPTEDEHEELQALGYWSLSHQ
RQVDSLTIQKSKEEIVRISCENEELRAKTKNNHAMARGRRIDNRLRLQMAAATFRFMQYWCCFVALVVFIYIAKNEGNPP
SEVIIALLGTSTISIVGLVGFVVSGLFKSNKDKE

Download         Length: 585 bp

>T212255 NZ_CP106999:c4215162-4214989 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 157 a.a.        Molecular weight: 17685.37 Da        Isoelectric Point: 7.2871

>AT212255 WP_260999559.1 NZ_CP080594:c3630340-3629870 [Cronobacter sakazakii]
MYNPICIVNEFIERAKKKGTDLTHMQAQKLLYIAHGYSLAFLNEPLLEEPVCAWRYGPVIPSVYYALRHNRSEPIADKAP
TTAIETETLDSKTASLLDMVYETYGKLSGVVLSEFTHRPGTPWSQAMGKRENIISDSSIKEYYLKLIKRDPVCNGL

Download         Length: 471 bp

>AT212255 NZ_CP106999:c4215486-4215190 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References