Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3521246..3521909 Replicon chromosome
Accession NZ_CP080594
Organism Cronobacter sakazakii strain Crono-684

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag K2Y34_RS16540 Protein ID WP_004385675.1
Coordinates 3521246..3521662 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID -
Locus tag K2Y34_RS16545 Protein ID WP_004385674.1
Coordinates 3521643..3521909 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K2Y34_RS16520 (K2Y34_16480) 3517234..3518967 - 1734 WP_004385679.1 single-stranded-DNA-specific exonuclease RecJ -
K2Y34_RS16525 (K2Y34_16485) 3518971..3519690 - 720 WP_080781176.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
K2Y34_RS16530 (K2Y34_16490) 3519713..3520609 - 897 WP_004385677.1 site-specific tyrosine recombinase XerD -
K2Y34_RS16535 (K2Y34_16495) 3520711..3521232 + 522 WP_004385676.1 flavodoxin FldB -
K2Y34_RS16540 (K2Y34_16500) 3521246..3521662 - 417 WP_004385675.1 protein YgfX Toxin
K2Y34_RS16545 (K2Y34_16505) 3521643..3521909 - 267 WP_004385674.1 FAD assembly factor SdhE Antitoxin
K2Y34_RS16550 (K2Y34_16510) 3522187..3523176 + 990 WP_004385673.1 tRNA-modifying protein YgfZ -
K2Y34_RS16555 (K2Y34_16515) 3523281..3523934 - 654 WP_004385672.1 hemolysin III family protein -
K2Y34_RS16560 (K2Y34_16520) 3524077..3524391 - 315 WP_004385671.1 N(4)-acetylcytidine aminohydrolase -
K2Y34_RS16565 (K2Y34_16525) 3524568..3525296 + 729 WP_004385670.1 MurR/RpiR family transcriptional regulator -
K2Y34_RS16570 (K2Y34_16530) 3525448..3526881 + 1434 WP_004385669.1 6-phospho-beta-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 16446.46 Da        Isoelectric Point: 11.4887

>T212254 WP_004385675.1 NZ_CP080594:c3521662-3521246 [Cronobacter sakazakii]
VVLWHSDLRVSWRSQWLSLLLHGAVAVIILLLPWPLRYLPVWMLLLSLVVFDCVRSQRRINAFQGEVSLTADYQLRWQGV
DWQICATPWMLRSGMMLRLRHPKTTRRHHVWLAADSMTEAEWRDLRRLLLQQPIGDKR

Download         Length: 417 bp

>T212254 NZ_CP106999:c4119378-4119028 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACACGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10358.84 Da        Isoelectric Point: 4.6289

>AT212254 WP_004385674.1 NZ_CP080594:c3521909-3521643 [Cronobacter sakazakii]
MDINNKARIHWACRRGMRELDISIMPFFEYDYDSLSDEDKCVFVRLLECDDPDLFNWLMNHGKPADAELARMVELIQQRN
QARGPVAL

Download         Length: 267 bp

>AT212254 NZ_CP106999:c4119623-4119372 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References