Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1604483..1605095 Replicon chromosome
Accession NC_007297
Organism Streptococcus pyogenes MGAS5005

Toxin (Protein)


Gene name parE Uniprot ID J7M9F1
Locus tag M5005_RS08135 Protein ID WP_010922665.1
Coordinates 1604760..1605095 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q5X9X9
Locus tag M5005_RS08130 Protein ID WP_002988079.1
Coordinates 1604483..1604770 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5005_RS08105 1599660..1600643 - 984 WP_002982755.1 tagatose-bisphosphate aldolase -
M5005_RS08110 1600647..1601576 - 930 WP_010922663.1 tagatose-6-phosphate kinase -
M5005_RS08115 1601624..1602139 - 516 WP_002988082.1 galactose-6-phosphate isomerase subunit LacB -
M5005_RS08120 1602174..1602602 - 429 WP_010922664.1 galactose-6-phosphate isomerase subunit LacA -
M5005_RS08125 1603049..1603822 + 774 WP_002982738.1 DeoR/GlpR family DNA-binding transcription regulator -
M5005_RS08130 1604483..1604770 + 288 WP_002988079.1 DNA-damage-inducible protein J Antitoxin
M5005_RS08135 1604760..1605095 + 336 WP_010922665.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M5005_RS09970 1605247..1605717 + 471 Protein_1539 integrase -
M5005_RS09605 1605763..1606200 + 438 WP_076639988.1 site-specific integrase -
M5005_RS08145 1606320..1606712 - 393 WP_002982716.1 30S ribosomal protein S9 -
M5005_RS08150 1606733..1607179 - 447 WP_002982710.1 50S ribosomal protein L13 -
M5005_RS08155 1607397..1607603 - 207 WP_002982695.1 helix-turn-helix transcriptional regulator -
M5005_RS08160 1607600..1608106 - 507 WP_002988070.1 hypothetical protein -
M5005_RS08165 1608242..1609102 - 861 WP_002982687.1 DegV family protein -
M5005_RS08170 1609199..1609717 - 519 WP_002982682.1 NYN domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-105)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13185.99 Da        Isoelectric Point: 5.2144

>T21225 WP_010922665.1 NC_007297:1604760-1605095 [Streptococcus pyogenes MGAS5005]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKIIHYHSTKGYTLSKD
YIVLYHIEGEENRIVIDYLLPTQSDYIKLFK

Download         Length: 336 bp

>T21225 NC_007297:1604760-1605095 [Streptococcus pyogenes MGAS5005]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCATCCATTATCACAGCACTAAAGGTTATACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGATCGTTATTGATTACTTGCTTCCTACTCAAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10934.56 Da        Isoelectric Point: 5.2318

>AT21225 WP_002988079.1 NC_007297:1604483-1604770 [Streptococcus pyogenes MGAS5005]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp

>AT21225 NC_007297:1604483-1604770 [Streptococcus pyogenes MGAS5005]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAGGAAGTGAGGGCTGAACTTGGACTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB J7M9F1

Antitoxin

Source ID Structure
AlphaFold DB A0A4U7GX94

References