Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1170856..1171475 Replicon chromosome
Accession NZ_CP080594
Organism Cronobacter sakazakii strain Crono-684

Toxin (Protein)


Gene name Hha Uniprot ID A0A2S9UIC9
Locus tag K2Y34_RS05520 Protein ID WP_004386909.1
Coordinates 1170856..1171074 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A3Q9CL77
Locus tag K2Y34_RS05525 Protein ID WP_004386908.1
Coordinates 1171101..1171475 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K2Y34_RS05495 (K2Y34_05485) 1166992..1168893 + 1902 WP_014729414.1 methyl-accepting chemotaxis protein -
K2Y34_RS05500 (K2Y34_05490) 1169034..1169294 + 261 WP_004386912.1 type B 50S ribosomal protein L31 -
K2Y34_RS05505 (K2Y34_05495) 1169298..1169438 + 141 WP_004386911.1 type B 50S ribosomal protein L36 -
K2Y34_RS05510 (K2Y34_05500) 1169467..1169976 - 510 WP_007891920.1 YlaC family protein -
K2Y34_RS05515 (K2Y34_05505) 1170096..1170647 - 552 WP_004386910.1 maltose O-acetyltransferase -
K2Y34_RS05520 (K2Y34_05510) 1170856..1171074 - 219 WP_004386909.1 HHA domain-containing protein Toxin
K2Y34_RS05525 (K2Y34_05515) 1171101..1171475 - 375 WP_004386908.1 Hha toxicity modulator TomB Antitoxin
K2Y34_RS05530 (K2Y34_05520) 1171938..1175087 - 3150 WP_007848020.1 multidrug efflux RND transporter permease subunit AcrB -
K2Y34_RS05535 (K2Y34_05525) 1175109..1176314 - 1206 WP_007848022.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8598.02 Da        Isoelectric Point: 9.4828

>T212242 WP_004386909.1 NZ_CP080594:c1171074-1170856 [Cronobacter sakazakii]
MTTKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTAVWKFVR

Download         Length: 219 bp

>T212242 NZ_CP106999:c1812379-1812005 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14343.05 Da        Isoelectric Point: 4.7168

>AT212242 WP_004386908.1 NZ_CP080594:c1171475-1171101 [Cronobacter sakazakii]
MDEYSPKRHDIAQLKFLCESLYHDCLATLGENQHGWVNDPTSAVNLQLNDLIEHIASFGLNYKIKHEDDAALIEQLDEYL
DDTFMLFSNYGINAQDLQKWRKSGNRLFRCFVNASKENPVSLSF

Download         Length: 375 bp

>AT212242 NZ_CP106999:c1812836-1812468 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGATTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S9UIC9

Antitoxin

Source ID Structure
AlphaFold DB A0A3Q9CL77

References