Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 143261..144864 Replicon plasmid pCrono589-1
Accession NZ_CP080592
Organism Cronobacter sakazakii strain Crono-589

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag K1721_RS21190 Protein ID WP_032989758.1
Coordinates 143261..144580 (-) Length 440 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag K1721_RS21195 Protein ID WP_032989757.1
Coordinates 144583..144864 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K1721_RS21180 (K1721_21125) 138643..141174 - 2532 WP_032989763.1 malto-oligosyltrehalose synthase -
K1721_RS21185 (K1721_21130) 141171..142955 - 1785 WP_032989760.1 malto-oligosyltrehalose trehalohydrolase -
K1721_RS21190 (K1721_21135) 143261..144580 - 1320 WP_032989758.1 type II toxin-antitoxin system HipA family toxin Toxin
K1721_RS21195 (K1721_21140) 144583..144864 - 282 WP_032989757.1 helix-turn-helix transcriptional regulator Antitoxin
K1721_RS21200 (K1721_21145) 144995..145879 - 885 WP_032989754.1 siderophore-interacting protein -
K1721_RS21205 (K1721_21150) 145876..147087 - 1212 WP_032989752.1 MFS transporter -
K1721_RS21210 (K1721_21155) 147223..148971 + 1749 WP_032989750.1 IucA/IucC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid tet(A) / qnrS1 / blaLAP-2 / blaTEM-1B / catA2 / mph(A) / sul1 / qacE / aadA2 pla / vipA/tssB / vipB/tssC / mgtB / iucA / iucB / iucC / iutA 1..158317 158317


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(7-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(21-69)


Sequences

Toxin        


Download         Length: 440 a.a.        Molecular weight: 49062.05 Da        Isoelectric Point: 6.7173

>T212240 WP_032989758.1 NZ_CP080592:c144580-143261 [Cronobacter sakazakii]
MRRTARLALWMNGLPVGYWDKHNGEDRLTYLPEWIADPQGRPLSLSLPFTPGNQSYRGAQVRDYFDNLLPDSENIRRRLA
MRYRAQSLEPFDLLAELGRDCVGAIQLLPAGEAPEGLFTIRARPLSTVDIAAMLRHTAEAFPGQHGGEEELRLSIAGAQE
KTALLWHEDQWCLPEGNTPTTHIFKLPLGLVGNMQADMRTSIENEWLCAQLLAAWDIPVAHTQMAQFEEQKVLIVERFDR
RLSADGQWWLRLPQEDMCQALGVSPLRKYQADGGPGIGDIMTVLSRSENAQADRANFFRAQIIFWILAATDGHAKNFSIA
HLPGNRYHLTPLYDVLSAWPVIGPGNNQIAWQKCKLAMAVRSGSNYYHLSQIRRRHWLRQGELAGLSAAQVNDMIDALTA
SAPAVIARVADALPVDFPASLADVIFNGMRQQCVRLAAA

Download         Length: 1320 bp

>T212240 NZ_CP106999:1800235-1800486 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10532.02 Da        Isoelectric Point: 9.0637

>AT212240 WP_032989757.1 NZ_CP080592:c144864-144583 [Cronobacter sakazakii]
MNTRYPLKTLSQLRPLLVGFRKKQGLTQKEVSARLGVTQQTYARLEANPETASIERLFRVFNVLGIEMTLCETQAAETDA
PARDDSPAHREAW

Download         Length: 282 bp

>AT212240 NZ_CP106999:1800483-1800737 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References