Detailed information of TA system TA212237

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 3661937..3662456
• Replicon: chromosome
• Accession: NZ_CP080591
• Organism: Cronobacter sakazakii strain Crono-589

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: K1721_RS17415
• Protein ID: WP_032987973.1
• Coordinates: 3661937..3662224 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A423XZJ0
• Locus tag: K1721_RS17420
• Protein ID: WP_007796477.1
• Coordinates: 3662214..3662456 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K1721_RS17395 (K1721_17350)	3657200..3657730	-	531	WP_004386036.1	NAD(P)H-dependent oxidoreductase	-
K1721_RS17400 (K1721_17355)	3657833..3658714	+	882	WP_007871040.1	LysR family transcriptional regulator	-
K1721_RS17405 (K1721_17360)	3659010..3661145	+	2136	WP_032987971.1	anaerobic ribonucleoside-triphosphate reductase	-
K1721_RS17410 (K1721_17365)	3661465..3661929	+	465	WP_032987972.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
K1721_RS17415 (K1721_17370)	3661937..3662224	-	288	WP_032987973.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
K1721_RS17420 (K1721_17375)	3662214..3662456	-	243	WP_007796477.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
K1721_RS17425 (K1721_17380)	3662534..3664444	-	1911	WP_032987975.1	PRD domain-containing protein	-
K1721_RS17430 (K1721_17385)	3664558..3665298	-	741	WP_032987976.1	KDGP aldolase family protein	-
K1721_RS17435 (K1721_17390)	3665295..3666413	-	1119	WP_076737755.1	DgaE family pyridoxal phosphate-dependent ammonia lyase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-84)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-64)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10841.82 Da
• Isoelectric Point: 10.4635

>T212237 WP_032987973.1 NZ_CP080591:c3662224-3661937 [Cronobacter sakazakii]
MSYKLVFDPRALKEWHKLGETVKAQFKKKLAHVLAAPRVKSAWLSGLPDCYKIKLRTSGYRLVYQVRDDAVCVLVIAIGK
RENLTVYQGAGHRLE

Nucleotide

• Length: 288 bp

>T212237 NZ_CP106999:977325-977660 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9009.39 Da
• Isoelectric Point: 4.7719

>AT212237 WP_007796477.1 NZ_CP080591:c3662456-3662214 [Cronobacter sakazakii]
MATINVRLDDKLKNEAYAVLEKLGITPTEAVRLLFQYVAQNGRMPVKTLTVSDSEEALLRTVRERLADPQPGIRVDLDEL

Nucleotide

• Length: 243 bp

>AT212237 NZ_CP106999:977077-977325 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A423XZJ0