Detailed information of TA system TA212236

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 3498905..3499568
• Replicon: chromosome
• Accession: NZ_CP080591
• Organism: Cronobacter sakazakii strain Crono-589

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: K1721_RS16625
• Protein ID: WP_032987888.1
• Coordinates: 3498905..3499321 (-)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: A0A3Q9CFW7
• Locus tag: K1721_RS16630
• Protein ID: WP_007870701.1
• Coordinates: 3499302..3499568 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K1721_RS16605 (K1721_16565)	3494893..3496626	-	1734	WP_032987885.1	single-stranded-DNA-specific exonuclease RecJ	-
K1721_RS16610 (K1721_16570)	3496630..3497349	-	720	WP_004385678.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
K1721_RS16615 (K1721_16575)	3497372..3498268	-	897	WP_032987886.1	site-specific tyrosine recombinase XerD	-
K1721_RS16620 (K1721_16580)	3498370..3498891	+	522	WP_032987887.1	flavodoxin FldB	-
K1721_RS16625 (K1721_16585)	3498905..3499321	-	417	WP_032987888.1	protein YgfX	Toxin
K1721_RS16630 (K1721_16590)	3499302..3499568	-	267	WP_007870701.1	FAD assembly factor SdhE	Antitoxin
K1721_RS16635 (K1721_16595)	3499846..3500835	+	990	WP_032987889.1	tRNA-modifying protein YgfZ	-
K1721_RS16640 (K1721_16600)	3500940..3501593	-	654	WP_004385672.1	hemolysin III family protein	-
K1721_RS16645 (K1721_16605)	3501736..3502050	-	315	WP_032987891.1	N(4)-acetylcytidine aminohydrolase	-
K1721_RS16650 (K1721_16610)	3502228..3502956	+	729	WP_032988115.1	MurR/RpiR family transcriptional regulator	-
K1721_RS16655 (K1721_16615)	3503108..3504541	+	1434	WP_032987892.1	6-phospho-beta-glucosidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 16441.44 Da
• Isoelectric Point: 11.4887

>T212236 WP_032987888.1 NZ_CP080591:c3499321-3498905 [Cronobacter sakazakii]
VVLWHSDLRVSWRSQWLSLLLHGAVAVIILLLPWPLRYLPVWMLLLSLVVFDCVRSQRRINAFQGEVSLTADYHLRWQGV
DWQICATPWMLRSGMMLRLRHPKTTRRHHVWLAADSMTEAEWRDLRRLLLQQPVGDKR

Nucleotide

• Length: 417 bp

>T212236 NZ_CP106999:846265-846672 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10411.89 Da
• Isoelectric Point: 4.8310

>AT212236 WP_007870701.1 NZ_CP080591:c3499568-3499302 [Cronobacter sakazakii]
MDINNKARIHWACRRGMRELDISIMPFFEYDYDSLSDEDKRVFVRLLECDDPDLFNWLMNHGKPADAELARMVELIQQRN
QARGPVAL

Nucleotide

• Length: 267 bp

>AT212236 NZ_CP106999:846018-846284 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: A0A3Q9CFW7