Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1165004..1165623 Replicon chromosome
Accession NZ_CP080591
Organism Cronobacter sakazakii strain Crono-589

Toxin (Protein)


Gene name Hha Uniprot ID A0A2S9UIC9
Locus tag K1721_RS05545 Protein ID WP_004386909.1
Coordinates 1165004..1165222 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A3Q9CL77
Locus tag K1721_RS05550 Protein ID WP_004386908.1
Coordinates 1165249..1165623 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K1721_RS05520 (K1721_05530) 1161143..1163044 + 1902 WP_014729414.1 methyl-accepting chemotaxis protein -
K1721_RS05525 (K1721_05535) 1163184..1163444 + 261 WP_004386912.1 type B 50S ribosomal protein L31 -
K1721_RS05530 (K1721_05540) 1163448..1163588 + 141 WP_004386911.1 type B 50S ribosomal protein L36 -
K1721_RS05535 (K1721_05545) 1163617..1164126 - 510 WP_032989218.1 YlaC family protein -
K1721_RS05540 (K1721_05550) 1164246..1164797 - 552 WP_004386910.1 maltose O-acetyltransferase -
K1721_RS05545 (K1721_05555) 1165004..1165222 - 219 WP_004386909.1 HHA domain-containing protein Toxin
K1721_RS05550 (K1721_05560) 1165249..1165623 - 375 WP_004386908.1 Hha toxicity modulator TomB Antitoxin
K1721_RS05555 (K1721_05565) 1166086..1169235 - 3150 WP_007848020.1 multidrug efflux RND transporter permease subunit AcrB -
K1721_RS05560 (K1721_05570) 1169257..1170462 - 1206 WP_007848022.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8598.02 Da        Isoelectric Point: 9.4828

>T212223 WP_004386909.1 NZ_CP080591:c1165222-1165004 [Cronobacter sakazakii]
MTTKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTAVWKFVR

Download         Length: 219 bp

>T212223 NZ_CP106998:2670509-2670616 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14343.05 Da        Isoelectric Point: 4.7168

>AT212223 WP_004386908.1 NZ_CP080591:c1165623-1165249 [Cronobacter sakazakii]
MDEYSPKRHDIAQLKFLCESLYHDCLATLGENQHGWVNDPTSAVNLQLNDLIEHIASFGLNYKIKHEDDAALIEQLDEYL
DDTFMLFSNYGINAQDLQKWRKSGNRLFRCFVNASKENPVSLSF

Download         Length: 375 bp

>AT212223 NZ_CP106998:c2670462-2670396 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S9UIC9

Antitoxin

Source ID Structure
AlphaFold DB A0A3Q9CL77

References