Detailed information of TA system TA212222

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-Xre
• Location: 3905340..3906228
• Replicon: chromosome
• Accession: NZ_CP080590
• Organism: Devosia salina strain SCS-3

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: K1X15_RS19115
• Protein ID: WP_220305126.1
• Coordinates: 3905704..3906228 (+)
• Length: 175 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: K1X15_RS19110
• Protein ID: WP_220305125.1
• Coordinates: 3905340..3905711 (+)
• Length: 124 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K1X15_RS19090 (K1X15_19090)	3900530..3902188	-	1659	WP_220305121.1	AMP-binding protein	-
K1X15_RS19095 (K1X15_19095)	3902189..3902575	-	387	WP_220305122.1	hypothetical protein	-
K1X15_RS19100 (K1X15_19100)	3902572..3903732	-	1161	WP_220305123.1	thiolase family protein	-
K1X15_RS19105 (K1X15_19105)	3903717..3904895	-	1179	WP_220305124.1	hypothetical protein	-
K1X15_RS19110 (K1X15_19110)	3905340..3905711	+	372	WP_220305125.1	DUF2384 domain-containing protein	Antitoxin
K1X15_RS19115 (K1X15_19115)	3905704..3906228	+	525	WP_220305126.1	RES domain-containing protein	Toxin
K1X15_RS19120 (K1X15_19120)	3906449..3908497	-	2049	WP_220305127.1	hypothetical protein	-
K1X15_RS19125 (K1X15_19125)	3908865..3910352	+	1488	WP_220305128.1	IS21 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (12-166)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (71-120)

Sequences

Toxin

Protein

• Length: 175 a.a.
• Molecular weight: 19016.63 Da
• Isoelectric Point: 6.4828

>T212222 WP_220305126.1 NZ_CP080590:3905704-3906228 [Devosia salina]
MPDAEAAGPLILWRAYVPKWSYVPLSGDGAARFGGRWNPPGVPAIYAARELSTAWAEYNQGFVQHPALIAQLELAGARLA
DLTVPAVMEEHGFDQAIHRSEWRSELDKGEVPAPHLVYRQLFGAGFDGVIYPSFMSPGGSCVALWRWNSPGAPVLRVIDP
DGRLPTSPASWRKP

Nucleotide

• Length: 525 bp

>T212222 NZ_CP106998:c2382413-2382237 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin

Protein

• Length: 124 a.a.
• Molecular weight: 13299.18 Da
• Isoelectric Point: 8.4537

>AT212222 WP_220305125.1 NZ_CP080590:3905340-3905711 [Devosia salina]
MQAQGLDLGATRYGEEGSRFLSPQRLSEQLGVTQAELARLAGVARNTLTAKSATRKVDAALSPIVRILTLAAEMAGDESR
AVIWFKHQPIPGWAGKTAYDLVEERKADQVLAYLEAVRAGVYA

Nucleotide

• Length: 372 bp

>AT212222 NZ_CP106998:c2382191-2381775 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA