Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpA-brnA/BrnT_toxin-BrnA
Location 88020..88539 Replicon chromosome
Accession NZ_CP080590
Organism Devosia salina strain SCS-3

Toxin (Protein)


Gene name shpA Uniprot ID -
Locus tag K1X15_RS00460 Protein ID WP_220305579.1
Coordinates 88020..88292 (+) Length 91 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID -
Locus tag K1X15_RS00465 Protein ID WP_240549600.1
Coordinates 88324..88539 (+) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K1X15_RS00435 (K1X15_00435) 83669..84274 - 606 WP_220305575.1 hypothetical protein -
K1X15_RS00440 (K1X15_00440) 84373..84810 + 438 WP_220305576.1 Rrf2 family transcriptional regulator -
K1X15_RS00445 (K1X15_00445) 84891..85781 + 891 WP_220305577.1 NAD(P)/FAD-dependent oxidoreductase -
K1X15_RS00450 (K1X15_00450) 85841..86878 - 1038 WP_220305578.1 aldo/keto reductase -
K1X15_RS00455 (K1X15_00455) 86949..87989 + 1041 WP_240549599.1 rhodanese-related sulfurtransferase -
K1X15_RS00460 (K1X15_00460) 88020..88292 + 273 WP_220305579.1 BrnT family toxin Toxin
K1X15_RS00465 (K1X15_00465) 88324..88539 + 216 WP_240549600.1 BrnA antitoxin family protein Antitoxin
K1X15_RS00470 (K1X15_00470) 88627..89580 + 954 WP_220307361.1 LysR family transcriptional regulator -
K1X15_RS00475 (K1X15_00475) 89541..90344 - 804 WP_220305581.1 LytTR family DNA-binding domain-containing protein -
K1X15_RS00480 (K1X15_00480) 90422..90949 + 528 WP_240549601.1 DUF2306 domain-containing protein -
K1X15_RS00485 (K1X15_00485) 90962..91942 - 981 WP_220305582.1 ferritin family protein -
K1X15_RS00490 (K1X15_00490) 92093..92494 + 402 WP_220305583.1 hypothetical protein -
K1X15_RS00495 (K1X15_00495) 92557..93078 + 522 WP_220305584.1 DUF1775 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(5-82)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(10-64)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10457.86 Da        Isoelectric Point: 8.6391

>T212219 WP_220305579.1 NZ_CP080590:88020-88292 [Devosia salina]
MDFEWDDAKNEANVLKHGIDFADAVFIFRGPIVTWSDLRVDYGEMREISTGRMANTVIVTVVHTDRTGRRRIISARRASR
RERIVYETSI

Download         Length: 273 bp

>T212219 NZ_CP106998:1967178-1967281 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7972.94 Da        Isoelectric Point: 4.7085

>AT212219 WP_240549600.1 NZ_CP080590:88324-88539 [Devosia salina]
MKDEDIDFSDIPELDENFWQNARVVYPDGTSSVTLRVKNSVLEAFKADGKGYQTRMNAVLEAYVKATKKAG

Download         Length: 216 bp

>AT212219 NZ_CP106998:c1967319-1967048 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References