Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5366060..5366685 Replicon chromosome
Accession NZ_CP080584
Organism Klebsiella pneumoniae strain C1398 mutant C1

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag K2X23_RS26485 Protein ID WP_002882817.1
Coordinates 5366060..5366443 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag K2X23_RS26490 Protein ID WP_004150355.1
Coordinates 5366443..5366685 (-) Length 81 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K2X23_RS26470 (K2X23_26425) 5363426..5364328 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
K2X23_RS26475 (K2X23_26430) 5364325..5364960 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
K2X23_RS26480 (K2X23_26435) 5364957..5365886 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
K2X23_RS26485 (K2X23_26440) 5366060..5366443 - 384 WP_002882817.1 type II toxin-antitoxin system VapC family toxin Toxin
K2X23_RS26490 (K2X23_26445) 5366443..5366685 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
K2X23_RS26495 (K2X23_26450) 5366890..5367807 + 918 WP_002882812.1 alpha/beta hydrolase -
K2X23_RS26500 (K2X23_26455) 5367821..5368762 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
K2X23_RS26505 (K2X23_26460) 5368807..5369244 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
K2X23_RS26510 (K2X23_26465) 5369241..5370101 - 861 WP_002882807.1 virulence factor BrkB family protein -
K2X23_RS26515 (K2X23_26470) 5370095..5370694 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(7-112)

Antitoxin

(16-47)


Sequences


Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T212212 WP_002882817.1 NZ_CP080584:c5366443-5366060 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

>T212212 NZ_CP106998:846265-846672 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT212212 WP_004150355.1 NZ_CP080584:c5366685-5366443 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp

>AT212212 NZ_CP106998:846018-846284 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8


Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References