Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2713484..2715072 Replicon chromosome
Accession NZ_CP080584
Organism Klebsiella pneumoniae strain C1398 mutant C1

Toxin (Protein)


Gene name hipA Uniprot ID A0A0H3GN97
Locus tag K2X23_RS13425 Protein ID WP_004199851.1
Coordinates 2713484..2714806 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag K2X23_RS13430 Protein ID WP_002904790.1
Coordinates 2714806..2715072 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K2X23_RS13410 (K2X23_13390) 2708549..2711050 + 2502 WP_004199853.1 fimbria/pilus outer membrane usher protein -
K2X23_RS13415 (K2X23_13395) 2711038..2712042 + 1005 WP_004199852.1 fimbrial protein -
K2X23_RS13420 (K2X23_13400) 2712175..2713467 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
K2X23_RS13425 (K2X23_13405) 2713484..2714806 - 1323 WP_004199851.1 type II toxin-antitoxin system HipA family toxin Toxin
K2X23_RS13430 (K2X23_13410) 2714806..2715072 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
K2X23_RS13435 (K2X23_13415) 2715338..2715664 - 327 WP_002904788.1 hydroxyisourate hydrolase -
K2X23_RS13440 (K2X23_13420) 2715661..2716161 - 501 WP_002904787.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
K2X23_RS13445 (K2X23_13425) 2716139..2717518 - 1380 WP_004199850.1 nucleobase:cation symporter-2 family protein -
K2X23_RS13450 (K2X23_13430) 2717864..2719018 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
K2X23_RS13455 (K2X23_13435) 2718999..2719922 - 924 WP_004199849.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49128.44 Da        Isoelectric Point: 7.2487

>T212207 WP_004199851.1 NZ_CP080584:c2714806-2713484 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPLEQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T212207 NZ_CP106997:c4215162-4214989 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT212207 WP_002904790.1 NZ_CP080584:c2715072-2714806 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT212207 NZ_CP106997:c4215486-4215190 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GN97

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References